HIV合并HCV感染早期患者细胞免疫功能和病毒载量相关性

目的 探讨HIV与HCV合并感染早期患者细胞免疫功能和病毒载量的变化,为临床诊疗提供基础数据依据.方法 以广州市第八人民医院2017年1月—2019年12月收治HIV与HCV合并感染的首诊患者为研究对象,同时另选取HIV单独感染患者和HCV单独感染患者作为对照组.回顾性分析各组患者细胞免疫功能及病毒载量,并进行HIV与...

Correlation between cellular immune function and viral load in the early stage of HIV and HCV co-infection

Objective This study explored the interaction between HIV and HCV in vivo and the changes of cellular immune function in the early stage of co-infection, and provide important information for clinical diagnosis and treatment. Methods Patients with HIV and HCV co-infection admitted to the Eighth People's Hospital of Guangzhou from January 2017 to December 2019 were selected as the study subjects. Patients with HIV mono-infection or HCV mono-infection were selected as the control group. We retrospectively analyzed and compared the cellular immune function and viral load in each group, and discussed the correlation of HIV and HCV viral load, and the correlation of viral load with CD4⁺T lymphocytes. Results CD45⁺ lymphocyte count was 702.50 (443.25, 1 788.50) cells/μL, CD3⁺ lymphocyte count was 564.00 (356.00, 1 337.75) cells/μL, CD4⁺ lymphocyte count was 75.50 (25.50, 179.00) cells/μL, CD8⁺ lymphocyte count was 506.50 (315.50, 1 030.50) cells/μL, CD4⁺/CD8⁺ ratio was 0.13 (0.06, 0.23) in the HIV/HCV group ,and there were not significantly different from those in HIV group (P>0.05). CD45⁺, CD4+ lymphocyte count and CD4⁺/CD8⁺ ratio in HIV/HCV group were significantly lower than those in HCV group, with statistically significant differences (P<0.05). The HIV viral load was 4.82 (3.81, 5.54) log₁₀ copy/mL in HIV/HCV group and 5.24 (4.23, 6.00) log₁₀ copy/mL in HIV group, with no statistically significant difference between two groups (P>0.05). HCV viral load was 6.75 (4.77, 7.47) log₁₀ copy/mL in HIV/HCV group and 6.47 (5.91, 7.04) log₁₀ copy/mL in HCV group, with no statistically significant difference between two groups (P>0.05). There was obvious negative correlation between HIV viral load and CD4⁺T lymphocytes (r=-0.525, P=0.017), and no significant correlation between HCV viral load and CD4⁺T lymphocytes (P>0.05), and no significant correlation between HIV and HCV viral load in HIV/HCV group （r=-0.040, P=0.842）. Conclusion No interaction between HIV and HCV in the early stage of the HIV and HCV co-infection has been found.