| 冰片酯的合成、结构表征及工艺优化 |
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| 引用本文： | 陈传兵,伍海涛,宓穗卿,王宁生. 冰片酯的合成、结构表征及工艺优化[J]. 广州中医药大学学报, 2021, 38(4): 801-805 |
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| 作者姓名： | 陈传兵 伍海涛 宓穗卿 王宁生 |
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| 作者单位： | 广州中医药大学,广东广州 510405;广州中医药大学,广东广州 510405;广州中医药大学,广东广州 510405;广州中医药大学,广东广州 510405 |
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| 基金项目： | 国家自然科学基金资助项目(编号:30701100);广东省中药有效性与安全性研究重点实验室开放基金资助项目(编号:kf07005);广州中医药大学创新基金资助项目(编号:2007C002)。 |
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| 摘 要： | [目的]研究冰片酯的合成工艺.[方法]采用FT-IR、13CNMR、1HNMR证实冰片酯的结构,采用正交试验设计考察投料比、反应温度与反应时间对合成工艺的影响.[结果]正交实验结果显示,冰片酯的优化工艺条件为:冰片与酸投料比为1:1.2,反应温度为110℃,反应时间为6 h.[结论]该工艺对于更多冰片酯类衍生物的开发,...
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| 关 键 词： | 冰片酯 合成 工艺优化 冰片 |
Synthesis,Structural Characterization and Process Optimization of Borneol Ester |
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| CHEN Chuan-Bing,WU Hai-Tao,MI Sui-Qing,WANG Ning-Sheng. Synthesis,Structural Characterization and Process Optimization of Borneol Ester[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2021, 38(4): 801-805 |
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| Authors: | CHEN Chuan-Bing WU Hai-Tao MI Sui-Qing WANG Ning-Sheng |
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| Affiliation: | (Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China) |
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| Abstract: | Objective To study the synthesis process of borneol ester.Methods The structure of borneol ester was confirmed by FT-IR,13CNMR and 1HNMR.Orthogonal design was used to investigate the effect of reactant mole ratio,reaction temperature and reaction time on the synthesis process.Results The orthogonal design result showed that the condition of process optimization was as follows:reactant mole ratio of borneol and acid was 1∶1.2,reaction temperature was 110℃,reaction time was 6 h.Conclusion The synthesis process has certain reference value for developing more ramifications of borneol ester,broadening the application scope of Borneol. |
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| Keywords: | borneol ester synthesis process optimization borneol |
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