雷公藤多甙对急性前葡萄膜炎患者血清IL-2及TNF-α水平的影响

目的：探讨雷公藤多甙（TWP）对急性前葡萄膜炎（AAU）患者血清白细胞介素－2（IL－2）及肿瘤坏死因子（TNF－α）水平含量的影响。方法：将患者随机分为两组，观察组50例，以TWP治疗为主；对照组50例，以乙双吗啉治疗为主，对两组患者治疗前后进行血清IL－2及TNF－α水平含量检测，并与50例健康者对照。结果：观察组治疗前IL－2及TNF－α水平含量分别为（1．31±0．27）μg/L及（1．20±0．65）μg/L，治疗后为（1．19±0．27）μg/L及（0．96±0．54）μg/L，与治疗前比较差异均有显著性（t=2.22及2．00，P＜0．05）；对照组治疗前分别为（1．31±0．26）μg/L及（1．22±0．66）μg/L，治疗后为（1．20±0．27）μg/L及（0．98±0．51）μg/L，与治疗前比较差异均有显著性（t=2.08及2．03，P＜0．05）。观察组及对照组IL－2、TNF－α治疗前均明显高于健康组（P均＜0．05），而治疗后均接近健康组（P均＞0．05）。结论：（1）AAU患者存在IL－2及TNF－α异常改变；（2）TWP对AAU患者IL－2及TNF－α有明显抑制作用；（3）TWP治疗AAU临床疗效可靠。

Effect of Tripterygium Wilfordii Polyglycoside on Serum IL-2 and TNF-α in Patients with Acute Anterior Uveitis

OBJECTIVE: To explore the effect of Tripterygium wilfordii polyglycoside (TWP) on level of serum interleukin 2 (IL-2), and tumor necrosis factor alpha (TNF-alpha) in patients of acute anterior uveitis (AAU). METHODS: Patients of AAU were randomly divided into two groups. The treated group (n = 50) was mainly treated with TWP and the control group (n = 50) treated with bimolani. The level of IL-2 and TNF-alpha before and after treatment were determined and compared between the two groups and also compared between the treated group and normal group consisted of 50 healthy subjects. RESULTS: Levels of IL-2 and TNF-alpha in the treated group before treatment were 1.31 +/- 0.27 micrograms/L and 1.20 +/- 0.65 micrograms/L, and after treatment 1.19 +/- 0.27 micrograms/L and 0.96 +/- 0.54 microgram/L, those in the control group were 1.31 +/- 0.26 micrograms/L and 1.22 +/- 0.66 micrograms/L before treatment and 1.20 +/- 0.27 micrograms/L and 0.98 +/- 0.51 microgram/L after treatment respectively. Comparisons of the two parameters before and after treatment in both groups showed significant difference (P < 0.05 in TWP group and P < 0.01 in bimolani group). The two parameters in both treated groups were all higher than those in the normal group before treatment (P < 0.05), but showed insignificant difference after treatment (P > 0.05). CONCLUSION: Abnormal changes of IL-2 and TNF-alpha exist in AAU patients, TWP could suppress both parameters markedly therefore has a reliable effect in treatment of AAU.