Protective Effect of Radix Ginseng on Peroxidation Injury in Myocardium and Erythrocytes of Streptozocin－Induced Diabetic Rats

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Protective Effect of Radix Ginseng on Peroxidation Injury inMyocardium and Erythrocytes of Streptozocin-Induced Diabetic Rats

The authors have investigated the effect ot Radix Ginseng on peroxidation injury in my-ocardium and erythrocytes of streptozocin-induced diabetic rats. In the ginseng administered group (gin-seng solution 0. 2 g/200 g body weight once daily lasting 15-16 days) . there was a significant decreasein the level of fasting blood glucose and lipid peroxide in myocardium and erythrocytes, in comparison withthose of the model group (P<0. 05) . The superoxide dismutase activities in myocardium and erythrocytesof the ginseng group were increased (P<0. 05) . compared with those of the model group and the vitaminE treated group (vitamin E 10 mg/200 g.body weight once daily, lasting 15-16 days) . The results sug-gest that the mechanisms of antiperoxidation injury of ginseng might include the following: (1) loweringthe level of fasting blood glucose, decreasing monosaccharide autooxidation and partially protecting theproduction of free radicals; (2) elevating the activity of enzymatic free radical scavenger in cells, such assuperoxide dismutase, and (3) directly eliminating the superfluous free radicals.