| 尿甘氨酰脯氨酸二肽氨基肽酶在诊断肝硬化早期肾损害中的价值 |
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| 引用本文： | 刘泽军,赵安成. 尿甘氨酰脯氨酸二肽氨基肽酶在诊断肝硬化早期肾损害中的价值[J]. 实用医技杂志, 2008, 15(29): 4013-4014 |
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| 作者姓名： | 刘泽军 赵安成 |
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| 作者单位： | 1. 沂南县中医院,山东,沂南,276300
2. 临沂市沂水中心医院,山东,临沂,276400 |
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| 摘 要： | 目的:探讨应用尿甘氨酰脯氨酸二肽氨基肽酶(GPDA)诊断肝硬化早期肾损害的临床价值。方法:用本室建立的尿GPDA测定方法,检测87例肝硬化患者和70例正常对照组,并与尿N-乙酰-β-D-氨基葡萄糖苷酶(N-acetyl-β-D-glycosaminidase,NAG)进行比较。结果:与正常对照组比较,肝硬化患者尿GPDA明显升高,差异有显著性意义(P<0.01),肝硬化失代偿组明显高于肝硬化代偿组。87例肝硬化患者尿GPDA阳性检出率为43.2%,与尿NAG一致,尿GPDA与NAC呈显著正相关。结论:尿GPDA能敏感地反映肝硬化早期肾小管损伤,是一项具有良好临床应用价值的指标。
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| 关 键 词： | 甘氨酰脯氨酸二肽氨基肽酶 尿分析 肝硬化 肾损害 |
Clinical Study on Diagnostic Value of GPDA in Kidney Malfunction during Hepatocirrhosis |
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| LIU Ze-jun,ZHAO An-cheng. Clinical Study on Diagnostic Value of GPDA in Kidney Malfunction during Hepatocirrhosis[J]. Journal of Practical Medical Techniques, 2008, 15(29): 4013-4014 |
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| Authors: | LIU Ze-jun ZHAO An-cheng |
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| Affiliation: | LIU Ze-jun1; ZHAO An-cheng2(1.Yi’nan Hospital of Traditional Chinese Medicine; Yi’nan; Shandong 276300; China; 2.Yishui Central Hospital of Linyi; Linyi; Shandong 276400; China); |
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| Abstract: | Objective To investigate the prognosticated values of Glycyl-pro-line dipeptidyl aminopeptidas (GPDA) of renal malfunction during hepatocirrhosis. Methods Urine values of NAG and GPDA in 87cases of patients suffered from hepatocirrhosis and 70 healthy individuals were detected by urine analysis set by our lab. Results Values of GPDA were higher in hepatocirrhosis group than that in control group and the difference were significant (P<0.01).The values were higher in decompensate patients than in compensat... |
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| Keywords: | GPDA Urine analysis Hepatocirrhosis Kidney malfunction |
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