小细胞肺癌蛋白质组学研究进展

目的总结蛋白质组学在小细胞肺癌中的研究进展。方法应用PubMed、EMBASE及CNKI期刊数据库检索系统,以＂肺癌,小细胞肺癌、蛋白质组学和研究进展＂等为关键词,检索1995-01-2013-12的相关文献,共检索到英文文献556条,中文文献317条。纳入标准：1）小细胞肺癌;2）蛋白质组学研究;3）蛋白质组学技术。剔除标准：非小细胞肺癌。最后符合分析的文献24篇。结果目前蛋白质组学在小细胞肺癌中的研究主要集中于细胞、组织和血清三个方面,并且已发现多种不同的候选肿瘤标志。结论蛋白质组学研究已广泛深入到小细胞肺癌发病机制、临床早期诊断和治疗等各个方面,为发现小细胞肺癌诊断、治疗及预后判断的潜在生物标志提供了新的思路。

Progress in proteome research of small cell lung cancer

OBJECTIVE To summarize the progress of proteomics research of small cell lung cancer in recent years.METHODS A computer-based online search of PubMed,EMBASE database and CNKI database was undertaken for literature published from January 1995 to December 2013 with the key words of＂small cell lung cancer,proteomics,research progress＂in Chinese and English respectively.Totally 556 English literature and 317 Chinese literature are researched.Inclusive criteria：1）small cell lung cancer;2）Proteomics;3）Proteomics technology.Exclusion criteria：non-small cell lung cancer.Finally 24 articles were analyzed.RESULTS Currently the research of proteomics in small cell lung cancer focus on cells,tissues,and the studies have found many different candidate tumor markers.CONCLUSION Proteomics research has been widely implanted into pathogenesis,clinical early diagnosis and treatment of small cell lung cancer,and provides a new way for finding potential biomarker for diagnosis,treatment and prognosis of small cell lung cancer.