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| 磷酸二酯酶7:一个新的抗炎免疫药物靶点研究进展 | |
| 引用本文： | 张莉,杜冠华. 磷酸二酯酶7:一个新的抗炎免疫药物靶点研究进展[J]. 中国药理学通报, 2009, 25(1) |
| 作者姓名： | 张莉 杜冠华 |
| 作者单位： | 中国医学科学院北京协和医学院药物研究所国家药物筛选中心,北京,100050 |
| 基金项目： | 国家自然科学基金重点项目，中国医学科学院药物研究所科研重点与团队建设专项资助课题 |
| 摘 要： | 磷酸二酯酶(phosphod iesterases,PDEs)作为体内特异性水解第二信使cAMP和cGMP的唯一蛋白酶家族,参与多种生理病理过程。研究表明PDE7是cAMP特异性的,分为PDE7A、PDE7B两个亚型,主要分布在免疫和炎症细胞中。PDE7作为一个新的潜在抗炎免疫药物靶点,其选择性抑制剂有可能用于治疗慢性阻塞性肺疾病(COPD)、类风湿性关节炎、阿尔采末病(AD)等与免疫炎症密切相关的疾病。 |
| 关 键 词： | 环腺苷酸 磷酸二酯酶7 抗炎免疫 PDE7抑制剂 |
Progress in the study of phosphodiesterase-7 as a new target for anti-inflammatory and immune drug |
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| ZHANG Li,DU Guan-hua. Progress in the study of phosphodiesterase-7 as a new target for anti-inflammatory and immune drug[J]. Chinese Pharmacological Bulletin, 2009, 25(1) | |
| Authors: | ZHANG Li DU Guan-hua |
| Abstract: | Phosphodiesterases(PDEs) is the only protein enzyme family,which catalyze the hydrolysis of cyclic nucleotide second messages(cAMP and cGMP).PDEs regulate many physiologic and pathologic processes.Recent advance showed that PDE7 hydrolyze cAMP exclusively and is divided into PDE7A and PDE7B. PDE7 mainly express in immune and inflammatory cells.The selective inhibition of this family generates profound,functional effects and PDE7 has been used as a therapeutic target for diseases related with inflammation,such as chronic obstructive pulmonary disease(COPD),rheumatoid arthritis and Alzheimers disease(AD). |
| Keywords: | cyclic AMP PDE7 anti-inflammation and immunity PDE7 inhibitor |
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