Virilizing mature ovarian cystic teratomas |
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| Authors: | Antonio López-Beltrán Alfonso S. Calañas Pilar Jimena Alberto L. Escudero Telma R. Campello Manuel Muñoz-Torres Fernando Escobar-Jiménez Rafael E. Carvia F. F. Nogales |
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| Affiliation: | (1) Department of Pathology, Cordoba University Medical School and Reina Sofia University Hospital, Cordoba, Spain, ES;(2) Department of Internal Medicine (Endocrinology), Cordoba University Medical School and Reina Sofia University Hospital, Cordoba, Spain, ES;(3) Department of Gynaecology, Cordoba University Medical School and Reina Sofia University Hospital, Cordoba, Spain, ES;(4) Department of Pathology, University Medical School, Granada, Spain, ES;(5) Department of Endocrinology, University Medical School, Granada, Spain, ES;(6) Universidade Federal de Pernambuco, Brasil, |
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| Abstract: | ![]()
Three further cases of mature benign cystic teratomas of the ovary associated with virilization are added to the three previously reported in the literature. They were found in postmenopausal, obese, diabetic women aged 52, 61, and 67 years. The patients presented with hirsutism and voice changes and clitoromegaly was present in one. Testosterone and androstenedione levels were elevated but promptly regressed after removal of the tumours. Histologically, sheets of stromal luteinized cells were found peripherally at the interface between the neoplasm and ovarian tissue. Luteinization of ovarian stroma induced by an unknown factor related to diabetes mellitus is the origin of the virilization. Received: 8 January 1997 / Accepted: 28 February 1997 |
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| Keywords: | Ovary Androgen secretion Cystic teratoma Virilization Luteinization |
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