儿童斑秃与骨密度关系的初步探讨

目的:探讨儿童斑秃的发病与骨密度异常的关系。方法:对71例斑秃患儿[斑秃分为点状(<1cm)秃发、斑状(>1cm)秃发和普秃]及46例成人3种类型斑秃患者进行骨密度,血清锌、钙和铁测定比较及生活习惯调查。结果:儿童组斑秃患者中骨质疏松的阳性百分率明显高于成人斑秃组(P<0.001);儿童组斑秃患者中血清微量元素下降的百分率高于成人斑秃组,尤以锌元素下降明显,但无统计学意义(P>0.05);儿童组斑秃患者中血清锌和钙水平显著低于正常水平(P<0.05);骨密度下降斑秃患儿伴有“常吃零食”和“挑食”的不良生活习惯,并具有除斑秃以外的临床表现。结论:儿童斑秃,尤其是点状脱发和斑状脱发发病与骨密度异常的关系密切,此外血清锌、钙水平降低及不良生活习惯也与儿童斑秃发病有关。

Study of bone mineral density in the children with alopecia areata

Objective:To determine the relationship between bone mineral density(BMD)and the onset of alopecia areata in children.Methods:BMD and serum microelements of 71 children and 46 adults with alopecia areata were measured.Living habits were also surveyed.Results:The percentage of osteoporosis in alopecia children was much higher than that in the adults(P < 0.001).The percentage of low-level microelements was higher in alopecia children than that in the adults,especially for serum zinc.But there were no significant differences between them(P > 0.05).The levels of serum zinc and calcium in the children with alopecia areata were lower than those in normal ones(P < 0.05).The alopecia children with osteoporosis often had mal-living habits(such as socking and food selectivity).Conclusion:There are affinities between abnormal BMD and onset of alopecia areata in children.The low-levels of zinc and calcium and mal-living habits are also involved in this condition.