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| 依达拉奉对癫痫大鼠海马中MDR1产物P-gp表达的影响 | |
| 引用本文： | 刘松岩,王立威,谭东,杨宏,曹小帅,韩雪梅. 依达拉奉对癫痫大鼠海马中MDR1产物P-gp表达的影响[J]. 中国老年学杂志, 2011, 31(4) |
| 作者姓名： | 刘松岩 王立威 谭东 杨宏 曹小帅 韩雪梅 |
| 作者单位： | 1. 吉林大学中日联谊医院神经内科,吉林,长春,130033 2. 长春市人民医院 3. 长春市第二医院 |
| 基金项目： | 吉林省自然科学基金项目(No.200705268); 长春市科技计划项目(No.200808608SF14) |
| 摘 要： | 目的研究自由基清除剂依达拉奉对癫痫持续状态(SE)大鼠海马中多药耐药基因(MDR1)产物P-糖蛋白(P-gp)表达的影响,以探讨自由基清除剂对难治性癫痫(IE)的防治作用。方法成年SD大鼠随机分为对照组、模型组、依达拉奉组。采用氯化锂-毛果芸香碱腹腔注射制备癫痫持续状态模型,经腹腔注射给药,依达拉奉组于造模成功后即刻腹腔注射依达拉奉,2次/d,3 d后断头取海马,免疫组化检测P-gp表达,图像分析测其表达的灰度值。结果模型组P-gp表达明显高于对照组及依达拉奉组(P<0.01)。结论癫痫发作本身可能是IE的成因,依达拉奉通过清除自由基减轻神经元损伤,进而抑制P-gp表达,可能成为防治IE的有效方法。 |
| 关 键 词： | 难治性癫痫 P-糖蛋白(P-gp) 依达拉奉 |
Influence of edaravone on P-gp expression in hippocampus of epileptic rats |
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| LIU Song-Yan,WANG Li-Wei,TAN Dong,et al.. Influence of edaravone on P-gp expression in hippocampus of epileptic rats[J]. Chinese Journal of Gerontology, 2011, 31(4) | |
| Authors: | LIU Song-Yan WANG Li-Wei TAN Dong et al. |
| Affiliation: | LIU Song-Yan,WANG Li-Wei,TAN Dong,et al.Department of Neurology,China-Japan Union Hospital of Jilin University,Changchun 130033,Jilin,China |
| Abstract: | Objective By observing the effect of edaravone(EDA) on multidrug resistance permeability-glycoprotein(P-gp) expression in hippocampus of epileptic rats to explore prevention and treatment of radical scavenger on intractable epilepsy(IE).Methods 30 adult SD rats were randomly divided into control,model(status epilepticus(SE)) and EDA groups.SE model was established by injected lithium-pilocarpine intraperitoneal,EDA group were injected intraperitoneal,2 times a day.3 days later,hippocampus was obtained to ob... |
| Keywords: | Intractable epilepsy Glycoprotein(P-gp) Edaravone(EDA) |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |