急性脑脑卒中超敏C反应蛋白的动态演变及预后观察

目的:探讨急性脑卒中患者超敏C反应蛋白(hs-CRP)的动态演变与预后关系。方法:将急性脑卒中患者184例分为缺血性脑卒中102例(缺血组)和出血性脑卒中82例(出血组)。分别于治疗前、治疗后1、2、3、4、6、8周测血hs-CRP水平。并随访1年,观察再发脑卒中情况。结果:2例在发病后2周病死予以剔除。2组患者治疗后1~8周hs-CRP均较治疗前显著降低(P<0.01),治疗后2~8周hs-CRP亦均明显低于治疗后1周(P<0.01)。缺血组患者治疗前后1~8周hs-CRP水平均低于出血组(P<0.05~P<0.01)。2组随访观察1年,hs-CRP持续未恢复正常者再发脑血管病率为44.23%,高于hs-CRP恢复正常者的发生率为11.72%(P<0.01)。结论:急性缺血性脑卒中及急性出血性脑卒中发生后,hs-CRP均明显增高,但急性缺血性脑卒中hs-CRP恢复较急性出血性脑卒中快,hs-CRP持续未恢复者再发脑血管病的概率增高。

The relationship between the dynamic change of high sensitivity C-reactive protein and prognosis in patients with acute stroke

Objective:To investigate the relationship between the dynamic change of high sensitivity C-reactive protein( hs-CRP) and prognosis in patients with acute stroke. Methods:One hundred and eighty-four patients with acute stroke were divided into the ischemic stroke group(n=102) and hemorrhagic stroke group(n=82). The levels of hs-CRP in all patients were measured before treatment and after 1,2,3,4,6 and 8 weeks of treatment. The recurrence of stroke was observed during the 1-year of following up. Results:2 patients died after onset two weeks and were removaled. The levels of hs-CRP in two groups after treatment 1 to 8 weeks compared with prior treatment all decreased significantly(P<0. 01). The levels of hs-CRP after treatment 2 to 8 weeks compared with post-treatment 1 week decreased significantly too(P<0. 01). The level of hs-CRP in ischemic stroke group on prior treatment and post-treatment 1 to 8 weeks compared with hemorrhagic stroke group all decreased significantly(P<0. 05~P<0. 01). All patients were followed up for 1 year,the recurrence rate of stroke in the patients with abnormal hs-CRP level(44. 23%) was higher than that in the patients with normal hs-CRP level(11. 72%)(P<0. 01). Conclusions:The levels of hs-CRP in ischemic stroke group and hemorrhagic stroke group increase significantly,but the recovery of the level of hs-CRP in ischemic stroke group is more quick than that in hemorrhagic stroke group,and the recurrence rate of stroke in the patients with abnormal hs-CRP level increases.