甘精胰岛素联合阿卡波糖对初发2型糖尿病患者氧化应激的影响

目的：观察甘精胰岛素联合阿卡波糖用于初发2型糖尿病（T2DM）患者的疗效及对氧化应激的影响。方法：选取24例初发2型糖尿病患者，比较其治疗前后空腹血糖（FBG）、餐后血糖（PBG）、）、总胆固醇（TC）、三酰甘油（TG）、糖化血红蛋白（HbAlc）、血浆超氧化物歧化酶（SOD）、丙二醛（MDA）等相关指标，同时选择性别年龄相匹配的健康体检者20名作为对照，分析这些指标在治疗前后的变化。结果：24例受试者治疗前后的FBG、PBG、TC、TG及HbAlc含量的变化均有统计学意义（P〈0．05），治疗后血SOD水平较治疗前明显升高（P〈0．05），MDA水平较治疗前明显下降（P〈0．05），较健康正常人比较，SOD水平仍较低，MDA水平仍较高（P〈0．05）。结论：应用甘精胰岛素联合阿卡波糖治疗2型糖尿病，在降低血糖、血脂的同时，可以减轻2型糖尿病患者体内的氧化应激水平。

The Effects of Oxidative Stress on Insulin Glargine Combined with Acarbose on Treatment of Primary Type 2 Diabetes MelIitus

Objective： To observe the effects of oxidative stress on insulin glargine combined with aearbose on treatment of primary type 2 diabetes mellitus. Method： 24 of primary type 2 diabetic patients and 20 healthy persons were selected to match the sex and age. Fasting blood glucose （ FPG） , postprandial blood glucose （PBG） , total cholesterin （ TC ） , triglyceride （ TG } , glycosylated hemoglobin （ HbA1 c ） , total superoxide dismutase （ SOD ） and malondialdehyde （ MDA ） of serum were detected and compared variance of these markers before and after treatment. Result： Significant differences were identified in FPG, PBG, TC, TG and HbAlc between before and after treatment （ P〈0.05 ）. The level of SOD in diabetic group were significantly increased after treatment（ P〈0.05 ） ,but less than t.hat in healthy persons（ P〈0.05 ）. The level of MDA in diabetic group were significandy decreased after treatment（ P〈0.05 ）, but higher than that in healthy persons （ P 〈0.05）. Conclusion： Patients with type 2 diabetes using insulin glargine combined with acarbose could have ideal blood glucose level and decrease oxidative stress.