| 宫颈鳞癌患者外周血单个核细胞Th1/Th2平衡状态的研究 |
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| 引用本文： | 胡雅君,何啸兰,贺漪,肖宏.宫颈鳞癌患者外周血单个核细胞Th1/Th2平衡状态的研究[J].实用预防医学,2010,17(12):2350-2351. |
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| 作者姓名： | 胡雅君 何啸兰 贺漪 肖宏 |
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| 作者单位： | 湖北省武汉市第一医院妇产科,湖北,武汉,430022 |
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| 基金项目： | 武汉市卫生局课题基金(No.武卫2008-70) |
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| 摘 要： | 目的探讨宫颈癌患者外周血辅助T细胞1(Th1)和辅助T细胞2(Th2)型细胞因子的表达状况。方法 30例宫颈癌患者采集外周血,采用流式细胞分析法,检测患者外周血CD4+细胞胞内细胞因子干扰素γ(IFN-γ)和白介素4(IL-4)的表达。应用酶联免疫吸附方法(ELISA)检测培养上清IFN-γ、IL-4的水平,并与10例健康对照组进行比较。结果宫颈癌患者IFN-γ染色阳性(Th1)的细胞比例及培养上清IFN-γ浓度明显低于健康对照组,IL-4染色阳性(Th2)细胞比例及培养上清IL-4浓度在两组间差异无统计学意义。结论宫颈癌患者存在Th1/Th2细胞功能失衡,呈Th2优势应答模式,机体免疫抑制,导致肿瘤发生,同时为宫颈鳞癌的生物治疗提供靶点。
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| 关 键 词： | 宫颈癌 辅助T细胞1 辅助T细胞2 细胞因子 |
Pattern of Th1/Th2 in Peripheral Blood Mononuclear Cells of Patients with Cervical Squamous Cell Carcinoma |
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| HU Ya-jun,HE Xiao-lan,HE Yi,et al..Pattern of Th1/Th2 in Peripheral Blood Mononuclear Cells of Patients with Cervical Squamous Cell Carcinoma[J].Practical Preventive Medicine,2010,17(12):2350-2351. |
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| Authors: | HU Ya-jun HE Xiao-lan HE Yi |
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| Institution: | HU Ya-jun,HE Xiao-lan,HE Yi,et al.(Wuhan No.1 Hospital,Wuhan 430022,Hubei,China) |
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| Abstract: | Objective To investigate the immunological reaction state of T-helper1/T-helper2(Th1/Th2) cytokines expression in peripheral blood mononuclear cells (PBMCs) from patients with cervical squamous cell carcinoma. Methods CD4+ cells of peripheral blood were collected in 30 patients with cervical squamous cell carcinoma.Plasma interferon-r(IFN-r) and interleukin-4(IL-4) were measured by ELISA.10 healthy adults were served as control group. Results The expression of the plasma IFN-r and the plasma IFN/IL-4 in pat... |
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| Keywords: | Cervical carcinoma T-helper1/T-helper2 Cytokines |
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