| 肌内皮缝隙连接在失血性休克大鼠内皮依赖和非内皮依赖的血管舒/缩功能调节中的作用 |
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| 引用本文： | 杨光明,唐婧,李涛,徐竞,刘良明.肌内皮缝隙连接在失血性休克大鼠内皮依赖和非内皮依赖的血管舒/缩功能调节中的作用[J].中国现代应用药学,2011,28(1):1-4. |
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| 作者姓名： | 杨光明 唐婧 李涛 徐竞 刘良明 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所第二研究室，创伤、烧伤与复合伤国家重点实验室，重庆 400042;第三军医大学大坪医院野战外科研究所第二研究室，创伤、烧伤与复合伤国家重点实验室，重庆 400042;第三军医大学大坪医院野战外科研究所第二研究室，创伤、烧伤与复合伤国家重点实验室，重庆 400042;第三军医大学大坪医院野战外科研究所第二研究室，创伤、烧伤与复合伤国家重点实验室，重庆 400042;第三军医大学大坪医院野战外科研究所第二研究室，创伤、烧伤与复合伤国家重点实验室，重庆 400042 |
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| 基金项目： | 国家自然科学基金重点项目(30830053)；国家自然科学基金青年基金项目(30901559)；国家重点基础研究发展计划(973)资助项目(2005CB522601)；教育部创新团队研究计划资助项目(IRT0712) |
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| 摘 要： | 目的 研究肌内皮缝隙连接(myo-endothelial gap junction,MEGJ)通道在失血性休克大鼠肠系膜上动脉血管(SMA)的内皮依赖和非内皮依赖的血管收缩/舒张功能调节中的作用.方法 利用在体血管管径测定技术,观察MEGJ的阻断剂18α-甘草次酸(18α-GA)对非内皮依赖的血管收缩剂去甲肾上腺素(N...
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| 关 键 词： | 失血性休克 肌内皮缝隙连接 血管舒张/收缩功能 内皮依赖性 非内皮依赖性 |
| 收稿时间： | 2/8/2010 12:00:00 AM |
Effects of Myo-Endothelial Gap Junction on the Endothelium-Dependent and -Independent Vascular Relaxation/Constriction in Hemorrhagic Shock Rats |
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| YANG Guangming,TANG Jing,LI Tao,XU Jing and LIU Liangming.Effects of Myo-Endothelial Gap Junction on the Endothelium-Dependent and -Independent Vascular Relaxation/Constriction in Hemorrhagic Shock Rats[J].The Chinese Journal of Modern Applied Pharmacy,2011,28(1):1-4. |
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| Authors: | YANG Guangming TANG Jing LI Tao XU Jing and LIU Liangming |
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| Institution: | State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China;State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China;State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China;State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China;State Key Laboratory of Trauma, Burns and Combined Injury, Department 2, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China |
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| Abstract: | OBJECTIVE To observe the effects of myo-endothelial gap junction(MEGJ) on the endothelium-dependent and-independent vasorelaxation/vasoconstriction of superior mesenteric artery(SMA) in hemorrhagic shock rats.METHODS With determined the changes of diameter of SMA by a intravital microscope system,the effects of 18α-glycyrrhetic acid(18α-GA),a uncoupling agent of MEGJ,on endothelium-independent vascular contractile response to norepinepherine(NE),endothelium-independent relaxation reactivity to sodium nitroprusside(SNP),and endothelium–dependent contractile response to myricetin,endothelium-dependent relaxation reactivity to acetylcholine(ACh) in hemorrhagic shock rats were observed.RESULTS After treatment with 18α-GA(2 mg·kg-1),the endothelium-independent vasorelaxation/vasoconstriction of SMA induced by SNP(10 μg·kg-1) or NE(3 μg·kg-1) in hemorrhagic shock rats had no significant changes.While 18α-GA pretreatment significantly blocked the endothelium-dependent relaxation reactivity to ACh(2 μg·kg-1) and contractile response to myricetin(2 μg·kg-1),the vascular relaxation/contractile response of SMA to ACh or myricetin in 18α-GA group were decreased to 35.1% and 26.8% of the control group,respectively(P<0.01).CONCLUSION MEGJ played important role in the regulation of endothelium-dependent vasorelaxation/vasoconstriction in hemorrhagic shock rats. |
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| Keywords: | hemorrhagic shock myo-endothelial gap junction vasorelaxation/vasoconstriction endothelium-dependent endothelium-independent |
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