| 毛冬青皂苷在大鼠体内的药物动力学研究 |
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| 引用本文： | 李美芬,赵钟祥,林朝展,熊天琴,迟玉广,祝晨蔯. 毛冬青皂苷在大鼠体内的药物动力学研究[J]. 中药新药与临床药理, 2011, 22(2) |
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| 作者姓名： | 李美芬 赵钟祥 林朝展 熊天琴 迟玉广 祝晨蔯 |
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| 作者单位： | 广州中医药大学中药学院,广州,510006 |
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| 基金项目： | 国家自然科学基金(30901954); 广东省自然科学基金(9451040701003203); 高等学校博士学科点专项科研基金(20094425110088); 广州中医药大学创新基金(09CX015) |
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| 摘 要： | 目的研究毛冬青皂苷(ilexsaponin A1)静脉给药后在大鼠体内的药物动力学特性。方法大鼠尾静脉注射给予毛冬青皂苷ilexsaponin A1(30 mg/kg),用HPLC法测定血药浓度,采用DAS2.0软件分析其药代动力学参数。结果大鼠静脉给药后,ilexsaponin A1在体内呈二室模型分布,主要药代动力学参数为:t1/2(α)=3.542min,t1/(2β)=17.636 min,CL=0.02 L.min-1.kg-1,AUC(0→)t=1096 mg.min.L-1,tmax=5 min,Cmax=52.972 mg.L-1。结论该法可用于大鼠血浆中ilexsaponin A1的检测及其体内药物动力学研究;静脉给药后,ilexsaponin A1在大鼠体内分布和消除迅速。
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| 关 键 词： | 毛冬青皂苷(ilexsaponin A1) 药物动力学 高效液相色谱法 |
Pharmacokinetic Studies of Ilexsaponin A1 in Rats |
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| LI Meifen,ZHAO Zhongxiang,LIN Chaozhan,Xiong Tianqin,Chi Yuguang,ZHU Chenchen. Pharmacokinetic Studies of Ilexsaponin A1 in Rats[J]. Traditional Chinese Drug Research & Clinical Pharmacology, 2011, 22(2) |
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| Authors: | LI Meifen ZHAO Zhongxiang LIN Chaozhan Xiong Tianqin Chi Yuguang ZHU Chenchen |
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| Affiliation: | LI Meifen,ZHAO Zhongxiang,LIN Chaozhan,Xiong Tianqin,Chi Yuguang,ZHU Chenchen(School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China) |
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| Abstract: | Objective To investigate the pharmacokinetic characteristics of ilexsaponin A1 in rats after intravenous injection.Methods The HPLC was applied to determine the plasma concentration of ilexsaponin A1 in rats after intravenous injection of ilexsaponin A1(30mg/kg),and the pharmacokinetic parameters were calculated by DAS2.0 software.Results After intravenous injection of ilexsaponin A1 into the rats,the blood plasma concentration-time profiles of ilexsaponin A1 were fitted to the two-compartment model.The pha... |
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| Keywords: | Ilexsaponin A1 Pharmacokinetics HPLC |
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