结核病患者院内念珠菌属感染及药物敏感性

目的了解结核病患者医院内对念珠菌属的二重感染和药物敏感性试验结果。方法对2002年1月~2004年12月3年间共6 280份临床送检的标本进行真菌培养;并对部分阳性念珠菌样品进行5-氟胞嘧啶(5-FC)、氟康唑(FLC)、酮康唑(KET)和伊曲康唑(ITC)4种抗真菌药物的敏感性试验。结果6 280份标本共分离出念珠菌属2 767株,分离率为44.06%;其中白色念珠菌检出2 006株,阳性率占31.94%,其他依此为光滑念珠菌344株(5.48%)、热带念珠菌206株(3.28%)、克柔念珠菌95株(1.51%)和其他念珠菌与真菌116株(1.85%);对4种抗真菌药物的敏感率分别依次为:5-FC 93.79%I、TC 62.76%、FLC 51.03%和KET 47.59%。结论由于结核病需长期用药,因而念珠菌属的二重感染率较高,使患者病情加重,在4种抗真菌药物中,以5-氟胞嘧啶的抗念珠菌活性为最佳。

Nosocomial Candidal Infection among Tuberculosis Patients and Its Drug Sensitivity

OBJECTIVE To understand nosocomial candidal infection among tuberculosis patients and its drug(sensitivity).(METHODS) Totally 6280 clinical samples from Jan 2002 to Dec 2004 were cultured;and part of(positive) ones were tested their drug sensitivity to FC,FLC,KET and ITC.RESULTS From all cultured samples 2767 Candida strains(positive rate was 44.06%) were isolated.From them C.albicans,C.glabrata,C.tropicalis,C.krusei and other Candida were 2006, 344,206,95 and 116 strains,their positive rate was 31.94%,(5.48%),3.28%, 1.51% and 1.85%,respectively.Their drug sensitivity rate to four drugs were as follows: to FC was 93.73%,to TTC 62.76%,to FLC 51.03% and to KET was 47.59%. CONCLUSIONS The condition of(tuberculosis) patient would become serious due to higher dual infection rate by Candida after too long anti-(tuberculosis) treatment.Among the four kinds of drugs the FC has the best anti-candidal activity.