无抽搐电休克治疗难治性抑郁症的对照研究

目的探讨无抽搐电休克治疗难治性抑郁症的疗效及安全性。方法将52例难治性抑郁症患者随机分为研究组25例（在原抗抑郁治疗方案基础上联合无抽搐电休克）和对照组27例（继续原抗抑郁治疗方案），共观察4周，在治疗前及治疗第1，2，4周末采用汉密尔顿抑郁量表（HAMD）、治疗副反应量表（TESS）评定疗效及不良反应。结果研究组显效率为65．0％，明显高于对照组的18．5％（P〈0．01）。结论无抽搐电休克治疗是治疗难治性抑郁症安全有效的方法。

A comparative study of modified electroconvulsive therapy for refractory depression

Objective To explore the efficacy and side effects of modified electroconvulsive therapy （MECT） in treatment of refractory depression. Methods 52 patients with refractory depression were randomly divided into treatment group with MECT and control group with antidepressants as treatment for [our weeks. They were assessed and analyzed contrastively using Hamilton depression scale （HAMD） and Treatment Emergent Symptom Scale （TESS）. Results After four weeks treatment, the response rate in the treatment group and control group were 65. 0% and 18. 5% respectively. The HAMD and TESS data were remarkable favor the treatment group （P ~ 0.01）. Conclusions MECT is effective for refractory depression without severe side effects.