甲磺酸多沙唑嗪缓释剂治疗膀胱出口梗阻术后膀胱痉挛的临床观察

目的 探讨甲磺酸多沙唑嗪缓释剂(可多华)对膀胱痉挛的防治作用,总结膀胱痉挛的治疗措施方法 256例患者分为两组.实验组:可多华4 mg临睡前服用,维生素K3 8 mg 3次/d;对照组:溴丙胺太林15 mg 2次/d,维生素K3 8 mg 3次/d.结果 实验组和对照组在治疗后的膀胱痉挛发生率不同,经卡方检验,差异有统计学意义(P<0.01).结论 可多华可降低膀胱三角区及后尿道的平滑肌张力,从而解除膀胱痉挛.

Clinical therapeutic observation of doxazosin mesylate in treatment of vesical spasm in 256 patients undergoing surgery for relieving bladder outlet obstruction

Objective To study the preventive and therapeutic effect of doxazosin mesylate (Cardura) in the management of vesical spasm. Methods Two hundred and fifty six cases were randomized into two groups: the study group was given Cardura 4 mg at bedtime, while the control group was given probanthine 15 mg twice a day. All the patients were given 8 ng of Vitamin Ks three times a day. Results There was significant difference in the incidence of vesical spasm between study group and control group (P＜0.01). Conclusions Cardura can decrease the urethral closure pressure, and reduce excitability of bladder detrusor muscle. So it is effective for the relief of vesical spasm.