| 结核分枝杆菌感染者白细胞介素4和白细胞介素17A的检测 |
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| 引用本文： | 宋素景,舒景,马春会,吴江利,李丽华,周春英,范书平,宋淑霞. 结核分枝杆菌感染者白细胞介素4和白细胞介素17A的检测[J]. 临床荟萃, 2014, 0(6): 624-626 |
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| 作者姓名： | 宋素景 舒景 马春会 吴江利 李丽华 周春英 范书平 宋淑霞 |
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| 作者单位： | 宋素景 (正定县人民医院 检验科,河北 正定,050800)； 舒景 (正定县人民医院 检验科,河北 正定,050800)； 马春会 (正定县人民医院 妇产科,河北 正定,050800)； 吴江利 (正定县人民医院 内二科,河北 正定,050800)； 李丽华 (正定县人民医院 病理科,河北 正定,050800)； 周春英 (正定县人民医院 检验科,河北 正定,050800)； 范书平 (正定县人民医院 内二科,河北 正定,050800)； 宋淑霞 (河北医科大学基础医学院 免疫教研室,河北 石家庄,050017)； |
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| 摘 要： | 目的检测隐性结核感染者、活动性结核患者及健康人群白细胞介素(IL)-4和IL-17A水平。方法选择已确诊的活动性结核患者、隐性结核感染者及健康对照者,且所有入组者均注射过卡介苗。采用流式细胞术测定血清中的IL-4和IL-17A的水平。结果与正常对照组和隐性感染组比较,活动性结核组血清中的IL-4及IL-17A水平明显降低:IL-4(1.85±1.43)μg/L、(1.77±1.16)μg/L和(0.85±0.94)μg/L(P0.05);IL-17A(1.06±1.29)μg/L、(0.91±1.08)μg/L和(0.09±0.16)μg/L(P0.01);但正常对照组与隐性感染组之间IL-4、IL-17A比较差异均无统计学意义(P0.05)。结论可以根据结核分枝杆菌感染后产生IL-4和IL-17A的水平来区分活动性结核感染和隐性结核感染及健康人群。
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| 关 键 词： | 结核分枝杆菌 白细胞介素4 白细胞介素17A |
Interleukin-4 and interleukin-17A detection in mycobacterium tuberculosis infection patients |
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| SONG Su-jing,SHU Jing,MA Chun-hui,WU Jiang-li,LI Li-hua,ZHOU Chun-ying,FAN Shu-ping,SONG Shu-xia. Interleukin-4 and interleukin-17A detection in mycobacterium tuberculosis infection patients[J]. Clinical Focus, 2014, 0(6): 624-626 |
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| Authors: | SONG Su-jing SHU Jing MA Chun-hui WU Jiang-li LI Li-hua ZHOU Chun-ying FAN Shu-ping SONG Shu-xia |
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| Affiliation: | (la. Department of Laboratory ;b. Department of Obstetrics and Gynecology ;c. Department of Internal Medicine ; d. Department of Pathology ,nengding County People＇s Hospital ,Zhengding 050800 ,China 2. Department of Immunology, Basic Medical School, Hebei Medical University, Shijiazhuang 050017, China) |
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| Abstract: | Objective To detect the levels of interleukin-4 （IL-4 ） and IL-17A in the latent tuberculosis infection,active tuberculosis patients and healthy persons.Methods The selection involved the confirmed diagnosis of active tuberculosis,latent tuberculosis infection and the healthy controls,and all the subj ects of study were inj ected with Bacillus Calmette Guerin.The serum IL-4 and IL-17A levels were measured by flow cytometry.Results Serum IL-4 and IL-17A levels of active tuberculosis group were significantly decreased compared with those of healthy persons and the latent tuberculosis infection,IL-4（1.85±1.43）μg/L,（1.77±1.16）μg/L vs （0.85±0.94）μg/L（P〈0.05）;IL-17A（1.06± 1.29）μg/L,（0.91±1.08）μg/L vs （0.09±0.16）μg/L（P 〈0.01）.IL-4 and IL-17A between healthy persons and the latent infection are not sighificant.Conclusion Based on serum IL-4 and IL-17A after Mycobacterium tuberculosis infection, active tuberculosis patients,latent tuberculosis infection and healthy persons could be distinguished. |
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| Keywords: | mycobacterium tuberculosis interleukin-4 interleukin-17 A |
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