青年大肠癌92例发病与病理特点分析

目的:分析青年大肠癌的发病特点和病理特征与中老年大肠癌的不同,为青年大肠癌的预防和治疗提供理论依据。方法:总结我院5年间收治的92例年龄低于35岁青年大肠癌资料进行筛选和研究,对患者性别、内镜资料、临床表现、病理及c-erbB-2蛋白表达和治疗情况进行统计分析,与同期中老年病例作对照。结果:血色素测定女性组明显低于男性组(P<0.01);青年组大肠癌在内镜特征、肿瘤部位和c-erbB-2检测方面与中老年组患者并无差异,在粘液血便、排便习惯改变、肠梗阻发生率,粘液腺癌、未分化癌发生率,Dukes分期C-D期相比较,差异有显著性意义(p<0.05)。结论:青年人大肠癌确诊晚,误诊多,恶性度高,预后差;贫血可能是提示青年女性大肠癌具有诊断价值的参考指标;检测C-erbB-2蛋白表达可提示预后并指导临床治疗。

Analysis of Incidence and Pathological Characteristics of 92 Young Patients with Colorectal Carcinoma

Objective: To analyzes the incidence and pathological characteristic of colorectal carcinoma in young patients and to explore the possibility of screening and preventing hereditary colorectal carcinoma.Method: 92 young patients with colorectal carcinoma under 35 years of ages were reviewed as to their sex,endoscopes datum,clinic representation,pathology,expression of c-erbB-2 protein and cure effects.Result: The hemoglobin was lower in the female group than male group(p<0.001); The endoscopes datum,position and expression of C-erbB-2 protein of both groups showed no statistical difference,but the rate of mucor-bloody stools,change of bowel movement habit,adenocarcinoma,alvine block,mucinous adenocarcinoma,undifferentiated carcinoma,Dukes stage C and D were significant difference(p<0.05) in young group than old group.Conclusion: Colorectal carcinoma in young patients are lower diagnose,higher error diagnose,poorer differentiation of tumour,worse cure;Colorectal carcinoma in young females might present with anemia that should be excluded in differentiate diagnose;Expression of C-erbB-2 protein might be used as a prognostic marker for therapy.