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Substandard application of preimplantation genetic screening may interfere with its clinical success |
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| Authors: | Munné Santiago Gianaroli Luca Tur-Kaspa Ilan Magli Cristina Sandalinas Mireia Grifo Jamie Cram David Kahraman Semra Verlinsky Yury Simpson Joe L |
| Affiliation: | a Reprogenetics, Livingston, New Jersey b S.I.S.Me.R., Bologna, Italy c Reproductive Genetics Institute, Chicago, Illinois d Reprogenetics-Spain, Barcelona, Spain e New York University, New York, New York f Monash IVF, Clayton, Victoria, Australia g Istanbul Memorial Hospital, Istanbul, Turkey h Florida International University College of Medicine, Miami, Florida |
| Abstract: | The intent of this study was to evaluate a recent randomized clinical trial evaluating the effect of preimplantation genetic screening (PGS) that reports a negative effect on pregnancy outcome. This article reviews appropriate PGS techniques and how they differ from the trial in question. A closer look at the clinical trial in question reveals significant lack of expertise in biopsy, cell fixation, genetic analysis, and patient selection. At most, this trial demonstrates that in inexperienced hands, PGS can be detrimental. No other conclusions concerning the effect of PGS on pregnancy results can be drawn from the trial. |
| Keywords: | Preimplantation genetic diagnosis PGD recurrent miscarriage recurrent pregnancy loss aneuploidy |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |