血清CA72-4 CA19-9和恶性肿瘤特异性生长因子联合检测在胃癌诊断中的应用

目的探讨胃癌患者血清中CA72-4、CA19-9和恶性肿瘤特异性生长因子(TSGF)水平,以及3者联合检测在胃癌临床诊断中的意义。方法采用电化学发光免疫分析等技术检测60例胃癌患者(胃癌组)、55例胃良性疾病患者(良性疾病组)、50例健康体检者(对照组)血清CA72-4、CA19-9、TSGF水平,并对单项及组合检测诊断胃癌的敏感性、特异性、阳性预测值、阴性预测值进行比较,探讨其联合诊断的效能。结果胃癌组CA72-4、CA19-9、TSGF血清水平明显高于胃良性疾病组及健康对照组,3种标志物诊断胃癌的敏感性分别为62.4%、68.0%、54.4%;特异性分别为95.7%、86.6%、90.2%。3项联合检测敏感性提高到86.8%,与单项检测结果比较差异有统计学意义(P0.05);同时特异性也具有较高水平,达95.3%。结论 CA72-4、CA19-9、TSGF可作为临床诊断胃癌的肿瘤标志物,3项联合检测可明显提高阳性检出率。

Clinical value of combined detection of CA72-4,CA19-9 and TSGF levels in diagnosis of gastric cancer

Objective To investigate the clinical value of CA72-4,CA19-9 and tumor specific growth factor（TSGF）in serum of gastric cancer patients and the significance of their combination detection in diagnosis of gastric cancer.Methods Serum levels of CA724,CA199 and TSGF were detected using electro chemiluminescence immunoassay（ECL）in 60 patients with gastric cancer,55 patients with gastric benign disease and 60 normal healthy controls.The diagnostic values of these tumor markers were analyzed by sensitivities,specificities,positive predictive value and negative predictive value.Results The levels of CA72-4,CA19-9 and TSGF in the gastric cancer group were significantly higher than those in gastric benign disease and normal healthy groups（P〈0.01）.The sensitivities were 42.8%,45.7% and 54.4%,respectively,and the specificities were 90.7%,86.6%,87.4%,respectively in gastric cancer.The sensitivity and speficity of combined detection of three items were 86.8% and 95.3% respectively.Conclusion CA72-4,CA19-9 and TSGF may be served as the serum tumor markers in the clinical diagnosis of gastric cancer.The combined detection of three kinds of serum tumor makers shows the higher clinical value in gastric cancer diagnosis.