| 白藜芦醇桂皮酸酯抗炎、降脂药理作用研究 |
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| 引用本文： | 栗进才,;汪电雷,;黄鹏,;刘耀武,;杜子伟. 白藜芦醇桂皮酸酯抗炎、降脂药理作用研究[J]. 甘肃中医学院学报, 2014, 0(5): 5-8 |
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| 作者姓名： | 栗进才, 汪电雷, 黄鹏, 刘耀武, 杜子伟 |
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| 作者单位： | [1]亳州职业技术学院药学院,安徽亳州236800; [2]安徽中医药大学,安徽合肥230038; [3]阜阳市肿瘤医院药剂科,安徽阜阳236018 |
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| 摘 要： | 目的通过对白藜芦醇桂皮酸酯进行初步抗炎、降脂作用的研究,为其进一步研究与开发提供实验依据。方法采用二甲苯致小鼠耳肿胀法、10%蛋清诱导大鼠足肿胀模型,小鼠腹腔注射75%蛋黄乳液建立高血脂模型,分别观察白藜芦醇桂皮酸酯的抗炎作用及降血脂作用。结果白藜芦醇桂皮酸酯能显著抑制蛋清所致大鼠足肿胀的形成,并可显著降低高血脂动物模型血清中甘油三酯（TG）、血清总胆固醇（TC）的浓度。结论白藜芦醇桂皮酸酯在抗炎、降脂方面表现出一定的生物活性,为进一步研究白藜芦醇桂皮酸酯提供了实验依据。
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| 关 键 词： | 白藜芦醇桂皮酸酯 抗炎 降脂 |
Study on the anti-inflammatory and anti-hyperlipidemia actions of resveratrol tricinnamate |
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| Affiliation: | Li Jincai , Wang Dianlei , Huang Peng , Liu Yaowu , Du Ziwei ( 1. Bozhou Vocational and Technical College, Bozhou 236800, China; 2. Anhui University of Chinese Medicine, Hefei 230038, China; 3. Fuyang Tumour Hospital, Fuyang 236018, China) |
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| Abstract: | Objective To study anti-inflammatory and anti-hyperlipidemia actions of resveratrol tricinnamate, and provide experimental basis for the further research and development. Methods The methods of xylene-in- duced ear edema in mice and edema of rats＇ hind-paw induced by egg albumin （10%o） were used to observe the anti-inflammatory effects of resveratrol tricinnamate. Hyperlipemia model by I.P. injection 75% yolk emulsion in rats were used to observe the effect of reducing blood lipid. Results Resveratrol tricinnamate remarkably inhibited xylene-induced ear edema and decreased edema of rats＇ hind-paw as well as reduced the concertration of TG and TC in hyperlipemia model. Conclusion Resveratrol tricinnamate has significant biological activity in anti-inflam- rnatory effect and reducing blood lipid. It can be regarded as the experimental basis for the further research. |
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| Keywords: | resveratrol tricinnamate anti-inflammatory anti-hyperlipidemia |
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