| 葛根素缓释片释放度的研究 |
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| 引用本文： | 景秋芳,任福正,沈永嘉.葛根素缓释片释放度的研究[J].中草药,2002,33(11):991-993. |
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| 作者姓名： | 景秋芳 任福正 沈永嘉 |
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| 作者单位： | 华东理工大学化学与制药学院,上海,200237 |
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| 摘 要： | 目的：研究以甲壳胺和海藻酸钠为复合骨架制备的葛根素缓释片的释放度。方法：考察了不同测定条件对释放度的影响，并对释放机制进行探讨。结果：采用篮法与桨法对释放度测定没有影响；不同转速在释放初期（1－2h)对药物释放有影响；不同PH值的释放介质对翻放速率有显著影响（P＜0．05）。结论：葛根素缓释片释放稳定，释放以扩散为主，溶蚀也起一定的作用。
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| 关 键 词： | 葛根素 缓释片 释放度 甲壳胺 海藻酸钠 复合凝胶骨架 |
| 文章编号： | 0253-2670(2002)11-0991-03 |
| 收稿时间： | 4/2/2002 12:00:00 AM |
| 修稿时间： | 2002年4月2日 |
Study on release of slow-released tablets of puerarin |
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| JING Qiu fang,REN Fu zheng and SHEN Yong jia.Study on release of slow-released tablets of puerarin[J].Chinese Traditional and Herbal Drugs,2002,33(11):991-993. |
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| Authors: | JING Qiu fang REN Fu zheng and SHEN Yong jia |
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| Institution: | College of Chemistry and Pharmacy, East China University of Science and Technology, Shanghai 200237, China;College of Chemistry and Pharmacy, East China University of Science and Technology, Shanghai 200237, China;College of Chemistry and Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Object To study the release mechanism of slow released tablet of puerarin (PUE) prepared by taking chistosan (CS) and sodium alginate (AL) as primary excipient. Methods The effect of the release in different conditions and the release mechanism was observed. Results No effect was found on release rate by basket and blade paddle methods, but the primary release (1 2 h) in different rotation speed showed the effect on drug release and the release rate was dependent on medium pH value (P<0 05). Conclusion The slow released tablet could release stably, and its release bases on diffusion, while erosion also does some work. |
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| Keywords: | puerarin slow-released tablet release rate |
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