复配式粗杂粮改善脂代谢紊乱作用的实验研究

目的探讨由米面和复配式粗杂粮等不同构成的饲料对脂代谢紊乱大鼠的作用。方法40只雄性SD大鼠随机分为阴性对照组、高脂模型对照组、米面组和粗杂粮组;以相应饲料连续喂养10周,测定各组大鼠体重、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)等指标,同时做肝脏组织病理检查。结果与高脂模型对照组比较,粗杂粮组大鼠的血清TG、TC水平显著下降,HDL-C水平显著升高,肝脏脂肪变性程度显著减轻。结论复配式粗杂粮对脂代谢紊乱大鼠脂代谢具有较好的改善作用。其特有的化学组分及生物学特性是取得较好效果的重要原因。

Effects of compound coarse grain on the disordered lipid metabolism in rats

To explore the effects of different feeds, including rise, flour and the compound coarse grain on the disordered lipid metabolism in rats. Methods 40 male SD rats were divided into 4 groups, including the negative control group, the hyperlipemic control group, the rlce-flour group and the compound coarse grain group. All 4 group rats were given different feeds for 10 weeks, body weights were weighted, serum TC, TG and HDL-C contents were determined and liver pathology were observed. Results When compared with the negative control group, the disordered lipid metabolism model was successfully made in hyperlipemic control group. When compared with the hyperlipemic control group, the serum TG and TC contents significantly declined and HDL-C significantly increased in the compound coarse grain group. Moreover, the conditions of liver cell fatty degeneration in compound coarse grain group were slight. Conclusion Compound coarse grain could improve the lipid metabolism in rats.