血管化鹿茸软骨组织与骨组织修复

BACKGROUND:Deer antlers are the only known mammalian organ that can regenerate periodically, and its cartilage is rich in blood vessels. Study on deer antler vascularized cartilage can uncover the antler biological characteristics and is of vital significance for bone repair and regenerative medicine.OBJECTIVE:To review the distribution of blood vessels in antler cartilage tissue, the generating process and mechanism of blood vessels, cytokines influncing angiogenesis, and to analyze the features of deer antler models in bone tissue engineering, providing medical reference for bone repair.METHODS: A computer-based online search of PubMed and CNKI databases was performed using the keywords of “deer antler, bone tissue engineering, vascularized cartilage” in English and Chinese, respectively. Articles concerning antler histology, morphology, antler cartilage and vascularized cartilage and bone tissue engineering were enrolled and repetitive studies and irrelevant articles were excluded. RESULTS AND CONCLUSION: Fifty-one eligible articles were selected finally. Deer antler is a kind of periodic regenerative bone, and antler cartilage is different from normal cartilage that is rich in blood vessels with the growth speed of 2.7 cm/day. Scholars have studied the vascularization of antler cartilage tissue, and obtained some achievements. Exploring the distribution of antler blood vessels in cartilage tissue, the generating process and mechanism of antler blood vessels, the cytokines acting on antler angiogenesis, as well as analyzing the advantages of deer antler model for bone tissue engineering provide a reference for tissue-engineered cartilage vascularization.中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Vascularized antler cartilage and bone tissue repair