胶原/丝素蛋白神经导管修复周围神经缺损的研究与应用进展 |
| |
作者姓名: | 徐云强 刘迎节 李瑞欣 朱双龙 张振辉 |
| |
作者单位: | 天津医科大学总医院骨科,天津市 300052;军事医学科学院卫生装备研究所,天津市 300161 |
| |
基金项目: | 国家自然科学基金青年基金资助项目(81101362) |
| |
摘 要: |
|
关 键 词: | 生物材料 材料相容性 胶原蛋白 丝素蛋白 三维打印 周围神经损伤 人工神经 神经支架 组织工程 冷冻干燥法 静电纺丝法 气体发泡法 国家自然科学基金 |
收稿时间: | 2016-07-06 |
Collagen/silk fibroin nerve conduits used for repairing peripheral nerve defect: application and development |
| |
Authors: | Xu Yun-qiang Liu Ying-jie Li Rui-xin Zhu Shuang-long Zhang Zhen-hui |
| |
Institution: | Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China; Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin 300161, China |
| |
Abstract: | BACKGROUND: Peripheral nerve defect due to limb dysfunction has always been the difficulty faced by the medical profession. Ideal materials and processing technology for constructing a tissue engineering scaffold targeting peripheral nerve repair are still in research stage.
OBJECTIVE: To review the research progress in peripheral nerve repair using collagen/silk fibroin nerve conduits.
METHODS:In this paper, the first author retrieved the PubMed and CNKI from 2003 to 2016 to search articles regarding methods of constructing artificial nerve scaffolds and selection of raw materials. Data from these articles were collected, summarized and analyzed.
RESULTS AND CONCLUSION: Forty-six articles were included for final analysis. Collagen and its degradation products trigger no inflammatory response in the host because of high biocompatibility and biodegradability. However, its use is largely limited by its rapid degradation and poor physical performance. Silk fibroin has a high flexibility and biocompatibility, and exhibits a slow degradation in vivo. As a rapid prototyping technique, three-dimensional printing can print various forms of scaffolds within a short time, characterized as high-quality pore structure and large-scale production. Given these, the collagen/silk fibroin nerve conduit prepared using the three-dimensional printing technology can maintain the biocompatibility and even improve the mechanical properties of the raw materials. Until now, more investigations on nerve repair using collagen or silk fibroin have been done, and we have never stopped improving the production process of these scaffolds. Therefore, the collagen/silk fibroin scaffold prepared using the three-dimensional printing technology is expected to become the main candidate for the repair of peripheral nerve defects. |
| |
Keywords: | Tissue Engineering Biocompatible Materials Stents |
|
| 点击此处可从《》浏览原始摘要信息 |
| 点击此处可从《》下载免费的PDF全文 |