新型可塑形同种骨修复材料修复运动性关节软骨损伤

A novel plastic homogeneous bone repair material for sport-related articular cartilage injury

BACKGROUND: Currently, the components and preparation methods of plastic bone repair materials remain controversial, and rare studies focus on their repair effects on sport-related articular cartilage injury.OBJECTIVE: To analyze the effect of a novel plastic homogeneous bone repair material to repair sport-related articular cartilage injury.METHODS: Thirty-six New Zealand rabbits were selected to prepare articular cartilage injury models, and were randomized into two groups. Model rabbits were repaired with the novel plastic homogeneous bone material (a composite of demineralized bone matrix and collagen) as experimental group, while the others repaired with sodium hyaluronate gel as control group. At 3 weeks after repair, treadmill system was utilized to stimulate sports training after athlete injury, for five consecutive sessions of 30 minutes each. At 16, 18 and 20 weeks after repair, the defect region was observed histologically.RESULTS AND CONCLUSION: At 16 weeks after repair, the defect region healed well and integrated with the surrounding tissues, and no significant inflammatory reaction appeared around the material in the experimental group; in the control group, a fissure appeared at the defect region but with no inflammatory reaction, and the material integrated with the interstitial site. At 18 weeks after repair, closely arranged acellular bone matrix could be found in the defect region, fibrous connective tissues were fewer, and there was a new bone formation around the edge of host bone in the experimental group; the defect region healed, but new bones were fewer in the control group. At 20 weeks after repair, the defect region in the experimental group was filled with fibrous connective tissues, in which there were numerous new blood vessels, and a few of new tissues appeared around the edge of host bone; the defect region in the control group was improved and no neovascularization occurred. These findings suggest that the novel plastic homogeneous bone material can promote the repair of sport-related articular cartilage injury with less rejection reactions.