| 丹参多酚酸盐对老年不稳定型心绞痛患者血清细胞因子水平的影响 |
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| 引用本文： | 吴兴利,裴翔,李德印,李金珉,杨丁友,高玉玲,朱梅,陈琪,王士雯. 丹参多酚酸盐对老年不稳定型心绞痛患者血清细胞因子水平的影响[J]. 中西医结合心脑血管病杂志, 2010, 8(2): 158-160 |
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| 作者姓名： | 吴兴利 裴翔 李德印 李金珉 杨丁友 高玉玲 朱梅 陈琪 王士雯 |
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| 作者单位： | 中国人民解放军总医院老年心血管疾病研究所,100853 |
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| 基金项目： | 中国人民解放军总后勤部重点课题基金 |
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| 摘 要： | 目的研究丹参多酚酸盐治疗对老年不稳定型心绞痛(UAP)患者血清细胞因子水平的影响。方法将72例UAP患者随机分为常规治疗组及丹参多酚酸盐治疗组(丹参多酚酸盐组),观察治疗前后血清白细胞介素18(IL-18)、白细胞介素1(IL-1)以及可溶性细胞间黏附分子-1(sICAM-1)水平的变化,并与18名正常对照组作比较。结果UAP患者血清IL-18、IL-1、sICAM-1水平较正常对照组明显升高(P0.01),常规治疗组治疗后血清IL-18、IL-1较治疗前降低(P0.05或P0.01),而在丹参多酚酸盐组IL-18、IL-1、sICAM-1均较治疗前明显降低(P0.01),且丹参多酚酸盐组治疗后较常规治疗组下降明显(P0.05或P0.01)。结论IL-18、IL-1和sICAM-1可能不同程度参与老年不稳定型心绞痛的病理生理进程。丹参多酚酸盐对UAP患者的心血管保护作用与其显著降低IL-18、IL-1以及sICAM-1水平,从而抑制冠脉局部的炎症级联反应有关。
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| 关 键 词： | 老年人 不稳定型心绞痛 丹参多酚酸盐 细胞因子 |
Effect of Salvianolate on Serum Cytokins Level in Elderly Patients with Unstable Angina Pectoris |
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| Wu Xingli,Pei Xiang,Li Deyin,et al Institute of Geriatric Cardiology,The General Hospital of the People's Liberation Army. Effect of Salvianolate on Serum Cytokins Level in Elderly Patients with Unstable Angina Pectoris[J]. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease, 2010, 8(2): 158-160 |
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| Authors: | Wu Xingli Pei Xiang Li Deyin et al Institute of Geriatric Cardiology The General Hospital of the People's Liberation Army |
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| Affiliation: | Wu Xingli,Pei Xiang,Li Deyin,et al Institute of Geriatric Cardiology,The General Hospital of the People's Liberation Army(Beijing 100853) |
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| Abstract: | Objective To investigate the effect of salvianolate on the serum cytokins level in elderly patients (pts) with unstable angina pectoris (UAP).Methods Seventy-two pts were divided randomly into conventional therapy group and salvianolate group.The levels of interleukin-18 (IL-18),interleukin-1 (IL-1) and intercellular adhesion molecular (ICAM-1) were evaluated by ELISA method before and 2 weeks after therapy.The levels of the cytokins were compared with 18 normal controls.Results The levels of serum IL-18,IL... |
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| Keywords: | elderly unstable angina pectoris salvianolae cytokins |
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