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HST1 and INT2 Gene Coamplification in a Squamous Cell Carcinoma of the Gallbladder |
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| Authors: | Tsuda, Toshitaka Nakatani, Hiroshi Tahara, Eiichi Sakamoto, Hiromi Terada, Masaaki Sugimura, Takashi |
| Affiliation: | 1Department of Pathology, Hiroshima University School of Medicine 1-2-3, Kasumi, Minami-ku, Hiroshima 734 2Genetics Division, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104 3National Cancer Center 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104 |
| Abstract: | The HST1 gene has previously been found to be amplified in over40% of squamous cell carcinomas of the esophagus. We performedSouthern blot analyses on squamous cell carcinomas of the lung,nasal cavity, uterine cervix and gallbladder, using HST1, INT2and five other on cogenes as probes. The HST1 and INT2 genes,both of which were mapped to chromosome 11 at band q13, werecoamplified in a squamous cell carcinoma of the gallbladder.The degree of amplification exceeded eight fold. |
| Keywords: | HST1 INT2 Amplification Squamous cell carcinoma Gallbladder |
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