| 非小细胞肺癌中凋亡相关蛋白与伴神经内分泌分化表达的相关性 |
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| 引用本文： | 李莉,任杰林,张黎,熊永炎.非小细胞肺癌中凋亡相关蛋白与伴神经内分泌分化表达的相关性[J].临床与实验病理学杂志,2008,24(3). |
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| 作者姓名： | 李莉 任杰林 张黎 熊永炎 |
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| 作者单位： | 1. 湖北省中山医院病理科,武汉,430033
2. 武汉大学中南医院病理科,武汉,430074 |
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| 基金项目： | 湖北省自然科学基金，湖北省科技攻关项目 |
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| 摘 要： | 目的 检测非小细胞肺癌(non-small cell lung carcinoma,NSCLC)中凋亡相关蛋白与神经内分泌(neuroendocrine,NE)分化的表达,探讨其相关性.方法 采用免疫组织化学染色方法,检测NSCLC组织中survivin,bcl-2蛋白与NSE、Syn及CgA等蛋白的表达,并进行相关性作统计学分析.结果 113例NSCLC中,survivin、bcl-2阳性表达率分别为88.5%、58.4%;NSE、Syn和CgA蛋白阳性表达率分别为53.6%、6.2%和26.5%.伴NE分化者占21.2%,其survivin蛋白表达明显高于不伴NE分化组,差异有统计学意义.结论survivin、bcl-2蛋白表达上调可能在NSCLC发生发展中起重要作用.伴NE分化的NSCLC与表达阴性者相比,以survivin为代表的抗凋亡能力明显增强.
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| 关 键 词： | 非小细胞肺癌 凋亡蛋白 神经内分泌分化 免疫组织化学 |
Relationship between expression of apoptosis-associated proteins and neuroendocrine differentiation in non-small cell lung carcinoma |
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| LI Li,REN Jie-lin,ZHANG Li,XIONG Yong-yan.Relationship between expression of apoptosis-associated proteins and neuroendocrine differentiation in non-small cell lung carcinoma[J].Chinese Journal of Clinical and Experimental Pathology,2008,24(3). |
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| Authors: | LI Li REN Jie-lin ZHANG Li XIONG Yong-yan |
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| Institution: | LI Li1,REN Jie-lin1,ZHANG Li1,XIONG Yong-yan2 (1Department of Pathology,Zhongshan Hospital of Hubei Province,Wuhan 430033,China,2Department of Pathology,Wuhan University Zhongnan Hospital,Wuhan 430074,China) |
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| Abstract: | Purpose To evaluate the espression of neuroendocrine(NE) markers and some apoptosis-associated proteins in non-small cell lung carcinoma(NSCLC) and to explore their relationship.Methods 113 cases of NSCLC were reviewed for subclassification.The immunohistochemical(IHC) methods were used to detect the expression of survivin,bcl-2,NSE,Syn and CgA.The results were analyzed with statistical methods.Results 100 tumours(88.5%) showed immunoreactivity for survivin and 66(58.4%) for bcl-2.61(53.6%) cases revealed I... |
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| Keywords: | non-small cell lung carcinoma apoptosis-associated protein neuroendocrine differentiation immunohistochemistry |
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