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| 依托泊苷鼻用黏附微球的性质考察及药动学研究 | |
| 引用本文： | 杨亚兰,杜青,敦洁宁. 依托泊苷鼻用黏附微球的性质考察及药动学研究[J]. 中国药学杂志, 2008, 43(4): 284-287 |
| 作者姓名： | 杨亚兰 杜青 敦洁宁 |
| 作者单位： | 河北医科大学药学院药剂学教研室,石家庄,050017 |
| 摘 要： | 目的通过对依托泊苷壳聚糖微球的黏附性、纤毛毒性及家兔体内药动学研究,评价其鼻腔给药的应用价值及作用。方法采用在体蟾蜍上颚纤毛评价微球的纤毛毒性,用纤毛输送速率考察黏膜黏附性;用HPLC测定不同剂型和不同给药方式家兔体内吸收情况。结果依托泊苷壳聚糖微球具有黏附性,无纤毛毒性;鼻腔给药后峰浓度(ρmax)为(85.99±3.52)μg·L-1,达峰时间(tmax)为(60.64±7.66)min。结论壳聚糖微球可以延长药物在鼻腔内的滞留时间,提高药物吸收,有很好的应用前景。 |
| 关 键 词： | 依托泊苷 鼻腔给药 药动学 壳聚糖微球 |
| 文章编号： | 1001-2494（2008）04-0284-04 |
| 收稿时间： | 2007-01-19 |
| 修稿时间： | 2007-01-19 |
Properties and Pharmacokinetic Studies on Etoposide-Loaded Chitosan Microspheres for nasal Administration |
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| YANG Ya-lan,DU Qing,DUN Jie-ning. Properties and Pharmacokinetic Studies on Etoposide-Loaded Chitosan Microspheres for nasal Administration[J]. Chinese Pharmaceutical Journal, 2008, 43(4): 284-287 | |
| Authors: | YANG Ya-lan DU Qing DUN Jie-ning |
| Affiliation: | Department of Phamaceutics，School of Pharmacy ，Hebei Medical University ，Shijiazhuang 050017，China |
| Abstract: | OBJECTIVE To investigate the mucoadhesive property,ciliotoxicity and pharmacokinetics for evaluaing the effects of etoposide-loaded chitosan microspheres for nasal administration.METHODS Mucoadhesive property and ciliotoxicity were evaluated with in situ toad palate model.High-performance Liquid Chromatograph was adopted for determining the concentration of etoposide in rabbit serum.RESULTS Chitosan microspheres had good mucoadhesive property and very low toxicity,after nasal administration.ρmax(85.99±3.52) μg·L-1 and tmax(60.64±7.66) min.CONCLUSION Chitosan microspheres could prolong the residence time of drug in the nasal cavity and increase the bioavailability of etoposide. |
| Keywords: | etoposide nasal administration pharmacokinetic chitosan micropheres |
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