消银合剂治疗血热证银屑病疗效及血清干扰素-γ、白介素-10检测

目的观察消银合剂对寻常性银屑病进行期血热证的临床疗效，并探讨其对银屑病Th1／Th2漂移的影响。方法选择寻常性银屑病进行期血热证患者60例，随机分为治疗组30例和对照组30例。治疗组给予消银合剂，对照组给予复方青黛胶囊，疗程8周。观察治疗前后PASI评分的变化，并测定30例治疗组患者治疗前后及20例正常对照者血清干扰素（INF）-γ、白介素（IL）-10水平。结果①治疗8周后，两组PASI积分均明显下降，治疗组PASI积分明显低于对照组（P〈0．05）。②治疗组有效率96．66％，优于对照组86．67％（P〈0．05）。③与正常对照相比，患者组INF-γ水平及INF-γ／IL-10比值明显升高，IL-10水平明显降低（P〈0．001）。治疗前PASI评分与血清INF-γ、IL-10水平均呈正相关（r=0．7，P〈0．001；r=0．43，P〈0．02）。治疗8周后，患者组血清INF-γ、IL-10水平，INF-γ/IL-10与健康对照组相比，无明显差异（P〉0．05）。结论消银合剂可能通过调节患者异常的INF-γ、IL-10水平而治疗银屑病。

Effects of Xiaoyin Decoction on the Serum Levels of Interferon-γ and Interleukin-10 in Patients with Psoriasis Vulgaris

Objective To investigate the clinical efficacy of Xiaoyin decoction in treatment of acute psoriasis vulgaris （APV） and to probe its influence on the excursion of Th1/Th2 of APV. Methods 60 patients with APV were randomly divided into treatment group and control group, and each group has 30 cases. The treatment group was treated with Xiao Yin decoction; the control group was treated with Cap FuFangQingDai. The course of treatment is 8 weeks. The serum level of Interferon-γ （INF-γ） and Interleukin-10（IL-10） from 30 patients of treatment group and 20 normal controls were tested by ABC-ELISA assay. Results ① The PASI scores of both group significantly declined after the treatment, the effective rates of treatment group and control group are significant difference （P〈0.05）. ②The level of INF-γ in serum from patients were significantly higher than that of normal control groups （P〈0.001）. The PASI scores has correlation with the increased serum level of INF-γ and IL-10 （r=0.7, P〈0.001; r=0.43, P〈0.02）. ③The level of IL-10 in serum from patients were significantly lower than that of normal control groups （P〈0.001）. ④The rates of INF-γ and IL-10 were significantly higher than those of normal control groups （P〈0.001）. ⑤After the treatment, the level of INF-γ and IL-10 in serum and the rates of INF-γ and IL-10 had no statistical difference between treatment group and control group. Conclusion The clinical efficacy of Xiaoyin decoction on treating acute APV is significantly higher than control group. The mechanism of Xiaoyin decoction on treating psoriasis might take effects through the regulation of the level of the two types of cytokines（INF-γ and IL-10）.