血管性痴呆大鼠模型的制备与评价

目的探讨制备理想的血管性痴呆动物模型方法。方法采用反复大鼠双侧颈总动脉缺血再灌注加剪尾放血法制备血管性痴呆大鼠模型，并对其进行行为学和生化学评价。结果行为学检测结果表明，血管性痴呆大鼠有明显的学习、记忆障碍，且该组大鼠海马组织乙酰胆碱含量持续降低。结论本方法可制备理想的血管性痴呆动物模型，用于血管性痴呆的基础研究及药物筛选或疗效评价。

Establishment and Evaluation of a Vascular Dementia Rat Model

Objective To establish a vascular dementia model in rats. Methods To establish a vascular dementia model by repeatedly clipping the common carotid artery and bloodletting from the rat tail, and to evaluate the model by testing the animal behavior and measurement of the acetylcholine content in hippocampus of the rats. Results The created rat vascular dementia model showed significant alteration in leaning and memory function, and obvious decreased content of acetylcholine in hippocampal tissues. Conclusion A rat model of vascular dementia has been successfully established. This rat model is useful for vascular dementia research and can be used in experimental studies, drug screening and evaluation of therapeutic effectiveness.