Smad2蛋白在宫颈癌组织中的表达及意义

目的 探讨Smad2蛋白在宫颈癌组织中的表达情况以及意义.方法 免疫组化法检测正常子宫组(NE组,n=61)和宫颈癌组(CC组,n=53)组织中Smad2蛋白的表达情况.结果 Smad2蛋白在NE组的表达阳性率是39.3％,在CC组的表达阳性率是77.4％,两组阳性率差异有统计学意义(P＜0.01).宫颈癌高分化和中低分化者的阳性率分别为52.6％和91.2％,差异有统计学意义(P＜0.01)；癌细胞浸润程度的越高≤1/2和＞1/2者阳性率分别是66.7％和91.3％,差异有统计学意义(P＜0.05).结论 Smad2蛋白在宫颈癌组织中表达减少,与宫颈癌浸润程度、癌细胞分化程度密切相关,通过检测Smad2蛋白提供临床诊断和预后的指标.

The expression and significance of Smad2 in cervical cancer tissue

Objective To explore the expression of Smad2 in cervical carcinoma and analyze the clinical signifieance of Smad2. Methods The expression of Smad2 in normal uterus group （ NE group, n = 61 ） and cervical carcinoma group （ CC group, n = 53 ） were detected by immunohistochemistry to analyze the significance of Smad2 in the cervical carcinoma. Results Positive rate of expression of Smad2 protein in NE group was 39.3 %, positive rate was 77.4% in CC group, statistical difference was found between the two groups（ P 〈 0.01 ）. The degree of differentiation of cervical cancer was lower, and the Smad2 positive rate was higher,well-differentiated and poorly differentiated were 52. 6% and 91.2% ,respectively,and the difference was statistically significante（ P 〈 0.01 ） ;The invasion of eaneer was higher, and the Smad2-positive rate was higher≤ 1/2 and 〉 1/2 were 66.7% and 91.30/0 , respectively, and the difference was statistically signifieante（ P 〈 0.05 ）. Conclusion The expression of Smad2 was less ; Smad2 was relat- ed to depth of invasion and degree of differentiation of cervical carcinoma, which could be used as clinical diagnosis and prognostic markers.