低钾型周期性瘫痪患者瘫痪程度相关因素分析

目的 分析影响低钾型周期性瘫痪(HOPP)患者肢体瘫痪程度的相关因素.方法 回顾分析80例HOPP患者的病历.应用单因素及多元回归分析探讨影响肢体瘫痪程度的相关因素.结果 单因素分析显示:伴发胸闷、心悸、恶心、呕吐以及肌肉酸痛患者,血清镁离子水平降低、血清钾离子水平极低、血清肌酸激酶水平升高以及伴心电图异常的患者瘫痪程度明显严重.多元回归分析发现血清镁<0.8 mmol/L(OR 8.3, 95% CI 1.0～68.4, P<0.05)、血清肌酸激酶>200 U/L(OR 1.1,95% CI 1.0～1.1, P<0.01)及血清钾1.5～1.8 mmol/L(OR1.3,95% CI 1.1～16.0, P<0.01)是影响HOPP患者瘫痪程度的独立危险因素.结论 血清镁离子水平降低、血清肌酸激酶水平升高及血清钾离子水平极低是HOPP患者重度肢体瘫痪的独立危险因素.

An analysis of the risk factors for the severity of paralysis in patients with hypokalemic periodic paralysis

Objectives To analyze the independent factors for the severity of paralysis in the patients with hypokalemie periodic paralysis (HOPP). Methods Eishty patients admitted with HOPP were reviewed. Using univariate analysis and multivariate analysis. the independent factors for the severity of paralysis were revealed. Results A total of 76 cases were male and 4 female with a mean age of (26.3±4.5) years. Univariate analysis showed that patients with low serum magnesium level, low serum potassium level, high serum creatine kinase level, changes of electrocardiogram, chest distress and palpitation, nausea and vomiting as well as muscular soreness had more severe paralysis, while multivariate analysis revealed that serum magnesium <0.8 mmol/L (OR 8.3,95% CI 1.0-68.4, P<0.05), serum potassium 1.5-1.8mmol/L (OR 1.3.95% CI 1.1-16.0, P<0.01) and serum creatine kinase >200 U/L (OR1.1.95% CI 1.0-1.1, P<0.01) were the independent factors for the severity of paralysis. Conclusion Low serum magnesium level. low serum potassium level and high serum creatine kinase level are the independent risk factors for more severe paralysis in patients with HOPP.