Blood gas changes following Priscoline administration in mitral stenosis and chronic lung diseases |
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| Affiliation: | 1. From the Cardiovascular Unit and Department of Internal Medicine B, Hadassah University Hospital, and Hebrew University-Hadassah Medical school, Jerusalem, Israel;1. Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;2. Department of Medicine, Duke University School of Medicine, Durham, North Carolina;3. Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;4. Department of Cardiac Surgery, Vanderbilt University Medical Center, Nashville, Tennessee;5. Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina;1. Respiratory Institute, Cleveland Clinic;2. Department of Quantitative Health Sciences, Cleveland Clinic;1. Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California;2. Division of Cardiology, Department of Internal Medicine, Seoul St. Mary''s Hospital, Catholic Research Institute for Intractable Cardiovascular Disease, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;3. Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;4. Division of Cardiology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea;5. Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea;6. Department of Transplant Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan;7. Department of Cardiothoracic Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California |
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| Abstract: | The O2 and CO2 content in the arterial blood of normal individuals and of patients with mitral stenosis and with chronic lung disease were examined in the resting state and ten minutes after the intravenous administration of Priscoline. In about half of the normal individuals a drop in the O2 content was observed after the drug; however, this change was statistically nonsignificant. In the majority of patients with mitral stenosis and with chronic pulmonary disease a statistically significant drop of the O2 content was observed while changes in the CO2 content varied. The observed drop in the arterial O2 content after administration of a drug known to cause vasodilation and augmented cardiac output is thought to be brought about by increased perfusion of poorly ventilated areas in the lungs and/or by increased flow through true intrapulmonary shunt vessels. |
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