Digitalis and the pulmonary circulation |
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| Affiliation: | 1. Department of Pharmacology, School of Medicine of the University of Pennsylvania, Philadelphia, Pa., USA;2. the Edward B. Robinette Foundation of the Hospital of the University of Pennsylvania, Philadelphia, Pa., USA;1. Nanotechnology and Integrated Bioengineering Centre, School of Engineering, Ulster University, York St, Belfast BT15 1AP, Northern Ireland, United Kingdom;2. School of Experimental Sciences and Technology, Rey Juan Carlos University, c/Tulipán s/n, 28933 Móstoles, Spain;3. São Carlos School of Engineering, University of São Paulo, Department of Hydraulics and Sanitation, Avenida Trabalhador São-carlense 400, São Carlos, São Paulo 13566-590, Brazil;4. Med-Micro Research Laboratory Pvt. Ltd, Nepal;5. Kantipur Dental College Teaching Hospital & Research Centre, Nepal;6. Institute of Applied Health Sciences (IAHS), School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, United Kingdom;7. Centro de Ciencia y Tecnología de Antioquia, Carrera 46 No. 56-11, Medellin, Colombia;8. Faculty of Engineering, University of Medellin, Ctra. 87, 30-65, Medellin 050026, Colombia;9. The Malawi University of Business and Applied Sciences (MUBAS), Department of Public and Environmental Health Sciences, Private Bag 303, Chichiri, Blantyre 3, Malawi;10. Cántaro Azul, Calle Franz Bloom 4, Barrio de Cuxtitali, San Cristóbal de Las Casas, Chiapas, Mexico;1. Institute of Plant Biology and Biotechnology, Almaty, 050040, Kazakhstan;2. The Ohio State University South Centers, Piketon, OH, USA;3. Kazakh National Agrarian Research University, Almaty, 050010, Kazakhstan;1. Department of Biological and Agricultural Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;2. Department of Process and Food Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia;3. Department of Agricultural and Biosystems Engineering, College of Engineering and Geosciences, Caraga State University, Butuan City 8600, Philippines;4. SMART Farming Technology Research Center (SFTRC), Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia |
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| Abstract: | In anesthetized dogs, the intravenous injection of acetyl strophanthidin caused a slight decrease in pulmonary arterial pressure which could not be explained by the effect on left atrial pressure. There was a marked decrease in the pulmonary venous flow, which was often accompanied by cardiac slowing and an increase in the calculated pulmonary vascular resistance. The cause of the increased pulmonary resistance is a combination of (a) the passive sive nature due to the decreased blood flow, and (b) local vasoconstriction of the perfused lung. The performance of vagotomy and thoracic sympathectomy, and the intravenous injection of bretylium excluded nervous factors as a cause of the vasoconstriction. |
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