| 茶多酚对镉毒性肾损伤的保护作用 |
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| 引用本文： | 李清钊,刘桂香,姚林,张艳淑,王广增,石俊,殷华,孟爱国. 茶多酚对镉毒性肾损伤的保护作用[J]. 工业卫生与职业病, 2002, 28(2): 102-103 |
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| 作者姓名： | 李清钊 刘桂香 姚林 张艳淑 王广增 石俊 殷华 孟爱国 |
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| 作者单位： | 1. 华北煤炭医学院预防医学系,河北,唐山,063000
2. 华北煤炭医学院附属医院,河北,唐山,063000 |
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| 摘 要： | 目的：研究茶多酚（TP））对镉（Cd)所致肾毒性作用的保护作用。方法：小鼠随机分为对照组，Cd组，Cd TP组，检测血清中尿素氮（BUN），肌酐（Cr)的含量，过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GSH－Px)活性，及肾脏光镜病理结构的变化。结果：与对照组比较，染镉小鼠血清中BUN，Cr均明显升高，小鼠血清中CAT，GSH－Px活性均明显下降，给PT治疗后，与染镉组比较，血清中的CAT，GSH－Px均上升，血清中的BUN，Cr的含量均有下降，且差异具有显著性，光镜结果表明，Cd TP组肾脏曲管上皮浊肿程度，肾小球间质充血程度均轻于Cd组，结论：TP对镉中毒性肾损伤有一定的拮抗作用。
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| 关 键 词： | 茶多酚 镉毒性 肾损伤 保护作用 |
| 文章编号： | 1000-7164(2002)02-0102-02 |
| 修稿时间： | 2001-01-18 |
Protective Effect of Tea Polyphenol on Cadmium Induced Renal Damage |
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| LI Qing|zhao,LIU Gui|xiang,YAO Lin,et al. Protective Effect of Tea Polyphenol on Cadmium Induced Renal Damage[J]. Industrial Health and Occupational Diseases, 2002, 28(2): 102-103 |
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| Authors: | LI Qing|zhao LIU Gui|xiang YAO Lin et al |
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| Abstract: | Objective To study the protective effect of tea polyphenol on cadmium induced renal damage.Methods Tea polyphenol was administrated to mice for 30 days.After exposed to cadmium chloride by ip.,the protective effect of tea polyphenol in kidney was observed.Results Contents of urea|nitrogen and creatinine in serum decreased in the experiment group compared with the control.Activities of catalase and glutathione peroxidase increased.It could be seen under microscope that the main damage induced by cadmium has been repaired after treating with tea polyphenol.Conclusions Tea polyphenol might have some protective effect on cadmium induced renal damage. |
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| Keywords: | Tea polyphenol Renal damage Cadmium |
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