| CD45RA和CD45RO抗原在白血病细胞上的表达及意义 |
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| 引用本文： | 李凤焕 沈德诚. CD45RA和CD45RO抗原在白血病细胞上的表达及意义[J]. 中华血液学杂志, 1997, 18(7): 343-346 |
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| 作者姓名： | 李凤焕 沈德诚 |
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| 摘 要： | 探讨ＣＤ４５ＲＡ和ＣＤ４５ＲＯ抗原在白血病及其亚型中的表达和分布及其在白血病鉴别诊断中的应用价值。
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| 关 键 词： | 免疫表型 白血病 抗原.CD_（45）RA 抗原.CD_（45）RO |
Expression of CD 45 RA and CD 45 RO antigens and its implication in leukemias |
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| F Li,D Shen,G Chen. Expression of CD 45 RA and CD 45 RO antigens and its implication in leukemias[J]. Chinese Journal of Hematology, 1997, 18(7): 343-346 |
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| Authors: | F Li D Shen G Chen |
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| Affiliation: | Institute of Hematology, CAMS and PUMC, Tianjin 300020. |
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| Abstract: | OBJECTIVE: To investigate the expression of CD45RA and CD45RO antigens in leukemias and its implication in the diagnosis and differential diagnosis of leukemias. METHODS: The expression of CD45 RA and CD45RO antigens and other markers on the surface of bone marrow or peripheral blood cells was investigated by indirect immunofluorescence in 104 cases of leukemias. Of them, 33 cases were ALL (23 of B-lineage ALL and 10 of T-ALL), 62 AML, and 9 B-CLL. RESULTS: Four patterns, CD45RA+/RO-, CD45 RA-/RO+, CD45RA+/RO+ and CD45RA-/RO-, were revealed. 87% of B-lineage ALL displayed CD45 RA+/RO-, 70% of T-ALL CD45RA-/RO+, and 78% of B-CLL CD45RA+/RO+, The frequency of the four patterns was 56% for CD45RA+/RO-, 18% for CD45RA-/RO+, 16% for CD45RA+/RO+ and 10% for CD45RA-/RO-, respectively in AML, and had no correlation with AML subtypes. CONCLUSION: CD45 isoform patterns could be served as supplementary tools for the differential diagnosis of B-lineage ALL, T-ALL and B-CLL. |
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| Keywords: | Immunophenotype Leukemia Antigen CD 45 RA Antigen CD 45 RO |
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