孕晚期高分辨率超声检测妊娠期高血压疾病血管内皮功能的研究

目的孕晚期应用高分辨力超声检测妊娠期高血压疾病患者的血管内皮依赖性舒张功能。方法对孕晚期76例妊娠期高血压疾病患者（研究组）和30例正常孕妇（对照组）,应用高分辨率超声测量静息状态下、反应性充血后、舌下含服硝酸甘油后的肱动脉内径,并计算反应性充血后和硝酸甘油诱发的内径变化率。结果（1）反应性充血试验诱发的肱动脉内径变化率研究组显著小于对照组,有极显著性差异（P〈0.01）,且研究组重度子痫前期组显著低于轻度子痫前期组及妊娠期高血压组,差异均有极显著性（P〈0.01）。（2）硝酸甘油诱发的肱动脉内径变化率研究组和对照组无显著性差异。结论妊娠期高血压疾病患者存在血管内皮依赖性舒张功能受损,可被高分辨超声检测,对其诊断、治疗、反映病情有一定指导意义。

Ultrasonographic detection on vascular endothelial function in patients with hypertensive disorders in pregnancy in the third trimester

Objective： To determine whether the vascular endothelial function in patients with hypertensive disorders in pregnancy （HDIP） was impaired in the third trimester. Methods： Seventysix patients with HDIP in the third trimester as studied group, 30 normotensive women as control group were studied, they were measured endothelial function by detecting the brachial artery during baseline, after reactive hyperemia and sublingual glyceryl trinitrate with high resolution ultrasonography , then calculate the changes of brachial arterial inner diameter respectively. Results ： （ 1 ） After reactive hyperemia, the percent change of studied group was significantly less than that of control group （ P 〈 0. 01 ）, and the percent change of inner diameter of severe pre - eclampsia group was significantly less than that of sligt pre- eelampsia group and gestational hypertension group （ P 〈 0. 01 ）. （2） No significant difference was found in percent change induced by sublingual glyceryl trinitrate between two groups . Conclusion： This study indicates that the function of endothelium - dependent dilation is impaired in patients with HDIP, and it can be detected by high resolution ultrasonography and can be used to diagnose and treat HDIP.