军团菌感染与肝硬化临床表现的关系

目的　调查肝硬化合并军团菌感染的情况 ,以引起临床医师的高度重视。方法　对 79例肝硬化患者的军团菌感染情况进行调查分析 (ELISA法检测IgM抗体 )。 结果　肝硬化合并军团菌感染者与非感染者临床症状比较 ,相对缓脉差异显著(P <0 .0 1) ,发热及腹泻也有显著差异 (P <0 .0 5 )。根据肝功能分级 ,肝硬化同级军团菌感染者与非感染者相比 ,血钠、血磷值(P <0 .0 5 )。 结论　 肝硬化患者除原发症状外 ,凡伴有发热、相对缓脉、水样腹泻、较严重的或难以纠正的低钠、低磷血症时 ,即使军团菌抗体检测阴性 ,仍然要考虑到军团菌感染 ,并采取经验性抗军团菌治疗

Relationship between Legionella infection and liver cirrhosis

Objective To study the situation of Legionella infection in the cirrhosis patients. Methods All of 79 liver cirrhosis patients were investigated with ELISA. Results The comparison between clinical symptoms in liver cirrhosis patients with and without Legionella infection showed that: relative bradycardia (P<0.01), diarrhoea (P<0.05), and pyrexia (P<0.05) had significant differences. Based on the Child-pugh grade of hepatic function, results were analyzed between the two groups in the same grade. The concentration of serum sodium and phosphorus also had significant difference (P<0.05). Conclusion Though the antibody can be negative in some cases, Legionella infection should be suspected and etiotropic therapy ought to be carried out if clinical symptoms of cirrhosis patients accompanied by pyrexia, relative bradycardia, watery diarrhea, severe or unmanageable hyponatremia and hyposphatemia.