| 皮肤晚期糖基化终末产物与2型糖尿病周围神经病变的相关性研究 |
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| 引用本文： | 刘茜,吴佳佳,王菊梅,董林,陈若平,叶山东. 皮肤晚期糖基化终末产物与2型糖尿病周围神经病变的相关性研究[J]. 安徽医药, 2015, 36(12): 1451-1453 |
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| 作者姓名： | 刘茜 吴佳佳 王菊梅 董林 陈若平 叶山东 |
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| 作者单位： | 230001 合肥 安徽医科大学附属安徽省立医院内分泌科,230001 合肥 安徽医科大学附属安徽省立医院内分泌科,230001 合肥 安徽医科大学附属安徽省立医院内分泌科,230001 合肥 安徽医科大学附属安徽省立医院内分泌科,230001 合肥 安徽医科大学附属安徽省立医院内分泌科,230001 合肥 安徽医科大学附属安徽省立医院内分泌科 |
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| 基金项目： | 中国科学院知识创新工程人才专项基金资助项目(项目编号:083RCl1184);十二五国家科技计划(项目编号:11070403050) |
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| 摘 要： | 目的 分析2型糖尿病(T2DM)伴周围神经病变(DPN)患者皮肤晚期糖基化终末产物(AGEs)水平变化及其临床意义.方法 选择99例T2DM患者,依据神经缺陷评分(NDS)将其分为DPN组和非DPN组,同时选取正常对照组(NC组)35例,测定各组皮肤AGEs和糖化血红蛋白(HbA1c)水平并进行比较.结果 与NC组相比,T2DM患者皮肤AGEs水平明显升高(P<0.05);与非DPN组相比,DPN组患者皮肤AGEs水平明显增(P<0.05),两组HbA1c水平差异无统计学意义(P>0.05).结论 T2DM患者皮肤AGEs水平升高可能参与糖尿病周围神经病变的发生.
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| 关 键 词： | 周围神经病变 2型糖尿病 晚期糖基化终末产物 |
| 收稿时间： | 2015-05-21 |
| 修稿时间： | 2015-08-12 |
Correlation between skin advanced glycation end products and diabetic peripheral neuropath |
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| Liu Qian,Wu Jiaji,Wang Jumei. Correlation between skin advanced glycation end products and diabetic peripheral neuropath[J]. Anhui Medical and Pharmaceutical Journal, 2015, 36(12): 1451-1453 |
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| Authors: | Liu Qian Wu Jiaji Wang Jumei |
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| Affiliation: | Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China,Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China,Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China,Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China,Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China and Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China |
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| Abstract: | Objective To analyze the level changes and clinical significance of skin advanced glycation end products(SAGEs)in patients of type 2 diabetes with peripheral neuropath. Methods According to Neurophy Disability Score, 99 patients with type 2 diabetes were divided into two groups, DPN group and non-DPN group; and 35 cases of non-diabetic patients were selected as normal controls. Results Compared with normal control group, SAGEs level was obviously increased in patients with diabetes(P<0.05), compared with non-DPN group, the level of SAGEs also increased in DPN group. There was no significant difference in the HbA1c level between DPN group and non-DPN group(P>0.05). Conclusion The SAGEs level is obviously increased in patients with type 2 diabetes, which may be involved in the pathogenesis of DPN. |
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| Keywords: | Peripheral neuropath disease Type 2 diabetes Advanced glycation end products |
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