| 度洛西汀和阿米替林对抑郁症患者生命质量的影响 |
| |
| 引用本文： | 王继辉,吴小立,魏钦令,韩自力.度洛西汀和阿米替林对抑郁症患者生命质量的影响[J].中国临床药理学与治疗学,2011,16(1):67-71. |
| |
| 作者姓名： | 王继辉 吴小立 魏钦令 韩自力 |
| |
| 作者单位： | 中山大学附属第三医院心理科,广州,510630,广东 |
| |
| 基金项目： | 2009广东省自然科学基金(9151008901000065) |
| |
| 摘 要： | 目的:研究度洛西汀和阿米替林对抑郁症患者生命质量的影响,以及生命质量和疗效及药物副作用的相关性。方法:将57例抑郁症患者随机分为度洛西汀组(研究组,30例)和阿米替林组(对照组,27例),疗程6周。在基线和1、2、4、6周后,给予评定健康状况问卷(SF-36)、汉密尔顿抑郁量表(HAMD)(24项版)、汉密尔顿焦虑量表(HAMA)、治疗过程出现症状量表(TESS)。结果:治疗6周后,研究组和对照组有效率相近,分别为86.67%(26/30)、85.19%(23/27),P>0.05;痊愈率相近,分别为46.67%(14/30)、44.44%(12/27),P>0.05;对照组不良反应发生率高于研究组(77.78%vs36.67%,P<0.05);治疗6周后,研究组SF-36各因子分均高于对照组(P<0.05)。SF-36多项因子分的提高和HAMD减分率、HAMA减分率成正相关,和TESS总分成负相关(P<0.05)。结论:度洛西汀对抑郁症患者生命质量的改善优于阿米替林;抑郁症患者生命质量和焦虑、抑郁情绪的改善及药物治疗的副作用密切相关。
|
| 关 键 词： | 抑郁症 生命质量 度洛西汀 阿米替林 |
A comparative study of efficacy on the quality of life between duloxetine and amitriptyline in treating patients with depression |
| |
| WANG Ji-hui,WU Xiao-li,WEI Qin-ling,HAN Zi-li.A comparative study of efficacy on the quality of life between duloxetine and amitriptyline in treating patients with depression[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(1):67-71. |
| |
| Authors: | WANG Ji-hui WU Xiao-li WEI Qin-ling HAN Zi-li |
| |
| Institution: | WANG Ji-hui,WU Xiao-li,WEI Qin-ling,HAN Zi-li Department of Psychology,3rd Affiliated Hospital,Sun Yat-sen University,Guangzhou 510630,Guangdong,China |
| |
| Abstract: | AIM : To study the efficacy on the quality of life between duloxetine and amitriptyline in treating patients with depression. METHODS : 57 patients were randomized to either duloxetine group(research group,n =30) or amitriptyline group(control group,n =27) for a 6-week period treatment.All patients were assessed with Short-Form-36 Health Survey(SF-36),Hamilton Depression Scale(HAMD,24-items),Hamilton Anxiety Scale(HAMA) and the Treatment Emergent Symptom Scale(TESS) before treatment and at the ends of the 1... |
| |
| Keywords: | Depression Quality of life Duloxetine Amitriptyline |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
