p21-ras、p53和VEGF在甲状腺乳头状癌中的表达及意义

目的　研究原癌基因Ras、抑癌基因p5 3及血管内皮生长因子 (VEGF)在甲状腺乳头状癌中的表达及相关性。方法　应用免疫组织化学S P法对 4 0例甲状腺乳头状癌中p2 1 ras、p5 3及VEGF的表达进行研究。结果　甲状腺乳头状癌中存在p2 1 ras、p5 3及VEGF的过度表达 ;VEGF的表达与p2 1 ras、p5 3的表达显著相关 (P <0 .0 5 ) ;VEGF的表达与甲状腺乳头状癌淋巴结转移显著相关 (P <0 .0 5 )。结论　p2 1 ras、p5 3、VEGF在甲状腺乳头状癌的发生发展过程中起重要作用 ;VEGF的表达与p2 1 ras、p5 3表达显著相关 ,可能受其调控。

Expression and significance of p21-ras,p53 and VEGF in papillary carcinoma of thyroid

Objective To study the relationship among the expression of oncog ene p21-ras,tumor suppress gene p53 and vascular endothelial growth factor(VEGF ) in human papillary carcinoma of thyroid. Methods Forty cases of papillary carcinoma of thyroid were studied by immunohistochemical method using antibodies to p21,p53 and VEGF. Results Overexpression of p21-ras,p53 and VEGF were found in papil lary carcinoma of thyroid. The expression of VEGF was correlated signific antly with the expression of p21-ras and with the expression of p53(P<0.05) .. A significant correlation was found between VEGF and lymph node metastasis in papillary carcinoma of thyroid (P<0.05). Conclusion p21-ras,p53 and VEGF have a important role in the init iation and development of human papillary carcinoma of thyroid. The expression o f VEGF are correlated significantly with the expression of p21-ras and with the expression of p53. The expression of VEGF might be regulated by Ras and p53.