北京奥运会期间大气质量与人群心率变异性关系的定组研究

目的 观察北京市奥运会期间大气污染物浓度变化情况,及其与人群心率变异性(HRV)之间的相关关系.方法 采用定组研究设计,筛选26例患有冠心病、心绞痛或具有至少1年以上心肌缺血症状的患者作为研究对象,在2008年6-9月进行5个周期的随访,测量其HRV指标及其他相关指标;收集同时期北京市环保局和气象局公布的每日大气污染物资料和气象资料,利用混合效应模型分析大气污染物浓度与人群HRV之间的相关关系.结果 通过单污染物线性混合效应发现HRV中总功率和高频功率与污染物大气颗粒物(PM10)、二氧化硫(SO2)和二氧化氮(SO2)浓度均呈负相关关系,PM10、SO2和NO2的浓度每下降10μg/m3总功率分别上升2.51%(95%CI值:-3.80%～-1.22%,t=-1.99,P=0.0497)、31.39%(95%CI值:-52.24%～-10.53%,t=-1.99,P=0.0497)和42.72%(95%CI值:-75.06%～-10.38%,t=-1.99,P=0.0497);高频功率分别上升3.46%(95%CI值:-5.14%～-1.77%,t=-2.11,P=0.0378)、40.63%(95%CI值:-68.70%～-12.56%,t=-2.11,P=0.0378)和53.76%(95%CI值:-97.97%～-9.56%,t=-2.11,P=0.0378).结论 大气污染物浓度的降低可改善易感人群的心血管功能.

The correlations between air quality and heart rate variability in aged susceptible people during Beijing Olympic Games 2008

Objective To observe the variations of the concentrations of air pollutants and explore the correlation between the heart rate variability (HRV) of the aged people and the air quality during Beijing Olympic Games 2008. Methods A panel study design was adopted. A total of twenty-six over 55-year-old patients with coronary heart disease or anginapectoris or a symptom of myocardial ischemia at least for one year were enrolled as a panel and followed up five times by measuring HRV index and other related indexes from June to September in 2008. The correlations between the HRV of the aged people and the air quality was analyzed with the linear mixed-effect models according to the data of air pollutants and meteorological conditions collected simultaneously from Beijing Environmental Protection Bureau and Beijing Meteorological Bureau. Results In single-pollutant mixed-effect models, the significant correlation was observed in the reduction of ambient PM10 ,SO2 and NO2 with the improvement of the total power and high-frequency power (HF) of HRV in the panel subjects,and a 10 μg/m3 decrease in PM10 ,SO2 and NO2 level was correlated with 2.51%(95%CI: -3.80% - -1.22% ,t= - 1.99,P=0.0497),31.39% (95% CI: -52.24% --10.53%,t= -1.99,P=0.0497) and 42.72% (95%CI: -75.06% - -10.38%,t= -1.99,P=0.0497) rises in total power of HRV respectively. A 10 μg/m3 decrease in PM10,SO2 and NO2 level was correlated with 3.46% (95% CI: -5.14% - - 1.77% ,t= -2.11 ,P=0.0378),40. 63% (95% CI: -68.70%--12.56%,t= -2.11,P=0.0378) and 53.76% (95%CI: -97.97% - -9.56%,t= -2. 11,P = 0. 0378) rises in high-frequency power (HF) of HRV respectively. Conclusion It suggests that the air pollution reduction could improve the cardiovascular functions of the susceptible population.