妇科手术术后抗凝药物干预时间对下肢静脉血栓形成的影响

目的：探究妇科手术术后低分子量肝素干预时间对下肢静脉血栓形成的影响。方法回顾性分析220例行经腹或经阴手术治疗患者的临床资料。根据患者术后低分子量肝素用药时间的不同将其分为A、B、C、D四组，分别为术后12、24、36、48 h给予低分子量肝素治疗，均于脐旁注射5000 IU的低分子肝素。观察各组患者术后的凝血功能情况以及下肢静脉血栓形成的发生率情况。结果 A、B两组患者的DV T发生率明显高于D组，组间比较差异显著且具有统计学意义；C组患者DV T发生率稍高于A、B两组，但稍低于D组患者，组间比较差异不显著，不具有统计学意义。结论低分子量肝素术后干预时机的不同对血栓形成的影响差别较大，术后24 h可作为低分子量肝素预防DV T形成的最佳时机。

Effect of gynecological operation postoperative anticoagulant drug intervention time on the formation of venous thrombosis of the lower limbs

Objective To explore the effect of low molecular weight heparin intervention time on venous thrombosis after gy‐necological operation .Methods 220 clinical data of patients with gynecological abdominal or vaginal surgery were retrospective analyzed .According to low molecular weight heparin treatment time of patients after gynecological operation ,A ,B ,C ,D four groups were divided ,which were given low molecular weight heparin respectively after 12 ,24 ,36 ,48 h ,were injected 5000 IU of low molecular weight heparin in parumbilical .The blood coagulation function and relatively deep vein thrombosis incidence of patients in each group were observed .Results The deep vein thrombosis (DVT) occurrences of group A ,B were significantly higher than group D ,the difference between groups was statistically significant .The DVT occurrence of group C was slightly higher than group A ,B ,but was slightly lower than group D ,the difference between the two groups was not statistically signifi‐cant .Conclusion The effect of low molecular weight heparin intervention time in the treatment on postoperative thrombosis was different .The 24 h postoperative could be the optimal timing in preventing thrombosis ,when low molecular weight heparin w as used .