补肾密骨液防治绝经后妇女代谢性骨质丢失的初步临床研究

４３例绝经５年之内的健康妇女随机分为治疗组和对照组，分别给服补肾密骨液和单味山药液。在治疗前后进行骨代谢生物化学指标，雌二醇及前臂骨密度测定。结果显示：给服补肾密骨液５个月后，其尺、桡骨骨矿含量较治疗前明显增加（Ｐ均＜０．０５），而对照组呈进行性减少。治疗组空腹尿钙，羟脯氨酸与肌酐比值较治疗前下降，且低于对照组（Ｐ均＜０．０５）；邮编４３００２２血清碱性磷酸酶治疗前后无显著差异（Ｐ均＞０．０５）。提示：补肾密骨液能够防治绝经后妇女的骨密度丢失，其机理与其能降低骨的吸收而不影响骨的形成有关。

Preliminary Clincal Study on Prevention of Bone Loss in Postmenopausal Women with the Bu Shen Mi Gu Ye

healtby women with the menopause within 5 years were randomly divided into thee carative and control groups. The curative group, Bu Shen Mi Gu Ye(BSMGY)was given orally; the control group, Rhizoma Dioscoreae medicinal decoction was given orally, Before and after treatment the comparative observation of two groups have been taken through some biochemical paramenters related to bone metabolism, serum estradiol and forearm bone density. The results showed that 5 months after treatment with BSMGY by oral administration, the ulnar and radial bone mineral content was higher than that of before the weatment (P<0.05), in the control group this index was continually decreased. The bone density were staticaly significant different in tow group(P<0.05). It appeared that BSMGY is able to prevent the bone loss in postmenopausal women, In the curative group ratio of fasting urinary calcium and hydroxyproline to creatinine was lower than that of before treatment and the control group (P<0.05),the concentration of serum alkaline phosphatase was no significant difference between tow group(P<0. 05). This preliminary study suggested that one of the therapeutic mechanism of BSMGY is probably due to declining bone resorption, without affecting bone formation in postmenopausal women.