(1) From the Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, USA;(2) Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Abstract:
Summary The present report describes two patients with fasting hypergastrinemia, gastric acid hypersecretion, andHelicobacter pylori gastritis. Provocative testing for Zollinger-Ellison syndrome was negative and imaging studies did not demonstrate an intra-abdominal mass. Following eradication of theHelicobacter pylori infection, the fasting hypergastrinemia resolved in both patients and in one patient the gastric acid hypersecretion also resolved. The implications of this case on the differential diagnosis of Zollinger-Ellison syndrome are discussed.