Two neuronal retinal components of the electroretinogram c-wave

Although the rising phase of the b-wave seems to be generated mainly in the rod bipolar cells and the cone on-bipolar cells, the slow component of the electroretinogram, the c-wave, evidently originates in the Müller cells and the pigment epithelium. The c-wave has three components. One cornea-positive component derives from the pigment epithelium, while a distal cornea-negative component (slow PIII) and a proximal slow component originate in the Müller cells. This third proximal component of the c-wave differs between mammalian species: it is negative in the rat retina, positive in the rabbit and human retina and may be lacking in the cat retina.